Publications

C-C Bond Forming Cross-Couplings C-X Bond Forming Cross-Couplings Olefin Functionalization Iridium-Catalyzed Allylic Substitution C-H Bond Functionalization Catalysis for Sustainable Energy & Polymers Fluorination and Fluoroalkylation Main-Group-Transition Metal Organometallics New Organometallic Reactions High Throughput Screening Combining Organometallics with Biocatalysis Reviews Commentary and Book Chapters
Methods Mechanism
348. Arlow, S.I.; Hartwig, J.F. Synthesis of Aryldifluoroamides by Copper-​Catalyzed Cross-​Coupling. Angew. Chem. Int. Ed.  2016,  55,  4567-4572.

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329. Ge, S.; Arlow, S.I.; Mormino, M.G.; Hartwig, J.F. Pd-Catalyzed α‑Arylation of Trimethylsilyl Enolates of α,α-Difluoroacetamides. J. Am. Chem. Soc.  2014,  136,  14401-14404.

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317. Mormino, M.G.; Fier, P.S.; Hartwig, J.F. Copper-Mediated Perfluoroalkylation of Heteroaryl Bromides with (phen)CuRF. Org. Lett.  2014,  16,  1744-1747.

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314. Ge, S.; Chaładaj, W.; Hartwig, J.F. Pd-Catalyzed α‐Arylation of α,α-Difluoroketones with Aryl Bromides and Chlorides. A Route to Difluoromethylarenes. J. Am. Chem. Soc.  2014,  136,  4149-4152.

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307. Hama, T.; Ge, S.; Hartwig, J.F. Palladium-Catalyzed α-Arylation of Zinc Enolates of Esters: Reaction Conditions and Substrate Scope. J. Org. Chem.  2013,  78,  8250-8266.

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289. Fier, P.S.; Hartwig, J.F. Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate. Angew. Chem. Int. Ed.  2013,  52,  1–5.

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288. Ge, S.; Hartwig, J.F. Highly Reactive, Single-Component Nickel Catalyst Precursor for Suzuki-Miyuara Cross-Coupling of Heteroaryl Boronic Acids with Heteroaryl Halides. Angew. Chem. Int. Ed.  2012,  51,  12837–12841.

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278. Fier, P.S.; Hartwig, J.F. Copper Mediated Difluoromethylation of Aryl and Vinyl Iodides. J. Am. Chem. Soc.  2012,  134,  5524–5527.

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265. Ge,  S.; Hartwig, J.F. Nickel-catalyzed Asymmetric α-Arylation and Heteroarylation of Ketones with Chloroarenes: Effect of Halide on Selectivity, Oxidation State and Room Temperature Reactions. J. Am. Chem. Soc  2011,  133,  16330-16333.

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260. Huang, D.S.; DeLuca, R. J.; Hartwig, J.F. α-Arylation of Esters Catalyzed by the Pd(I) Dimer [P(t-Bu)3]Pd(m-Br)]2. Org. Synth.  2011,  88,  4-13.

259. Liao, X.; Stanley, L.M.; Hartwig, J.F. Enantioselective Total Syntheses of (−)-Taiwaniaquinone H and (−)-Taiwaniaquinol B by Iridium-Catalyzed Borylation and Palladium-Catalyzed Asymmetric α-Arylation. J. Am. Chem. Soc.   2011,  133,  2088-2091.

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251. Huang, D.S.; Hartwig, J.F. Palladium-Catalyzed γ-Arylation of α,β-Unsaturated Esters from Silyl Ketene Acetals. Angew. Chem. Int. Ed.   2010,  49,  5757-5761 (designated as a "Hot Paper").

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211. Liao, X., Weng, Z., and J. F. Hartwig Enantioselective-Arylation of Ketones with Aryl Triflates Catalyzed by Difluorphos Complexes of Palladium and Nickel. J. Am. Chem. Soc.  2008,  130,  195-200.

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208. Vo, G.D., and J.F. Hartwig Palladium-Catalyzed α-Arylation of Aldehydes with Bromo- and Chloroarenes Catalyzed by [Pd(allyl)Cl]2 and DPPF or Q-phos.. Angew. Chem. Int. Ed.  2008,  47,  2127-2130.

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204. Hama, T.; Hartwig, J.F. Palladium-Catalyzed a-Arylation of Esters with Chloroarenes.. Org. Lett.  2008,  10,  1549-1552.

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203. Hama, T., and J.F. Hartwig a-Arylation of Esters Catalyzed by the Pd(I) Dimer {[P(t-Bu)3]PdBr}2.. Org. Lett.  2008,  10,  1545-1548.

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183. Takemiya, A., and J. F. Hartwig Palladium-Catalyzed Synthesis of Aryl Ketones by Coupling of Aryl Bromides with an Acyl Anion Equivalent. J. Am. Chem. Soc.  2006,  128,  14800-14801.

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178. Su, W.; Raders, S.; Verkade, J.G.; Liao, X; Hartwig, J.F. Palladium-Catalyzed alpha-Arylation of Trimethylsilyl Enol Ethers with Aryl Bromides and Chlorides. A Synergistic Effect of Two Metal Fluorides as Additives. Angew. Chem. Int. Ed.  2006,  45,  5852-5855.

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170. Hama, T., Culkin, D. A., and J. F. Hartwig Palladium-Catalyzed Intermolecular a-Arylation of Zinc Amide Enolates under Mild Conditions. J. Am. Chem. Soc.  2006,  128,  4976-4985.

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155. Limmert, M. E., Roy, A. H., and J. F. Hartwig Kumada Coupling of Aryl and Vinyl Tosylates under Mild Conditions. J. Org. Chem.  2005,  127,  9364-9370.

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151. Wu, L. and J. F. Hartwig Mild Palladium-Catalyzed Selective Monoarylation of Nitriles. J. Am. Chem. Soc.  2005,  127,  15824-15832.

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140. Leitner, A., Larsen, J., Steffens, C. and J. F. Hartwig Palladium-Catalyzed Addition of Mono- and Dicarbonyl Compounds to Conjugated Dienes. J. Org. Chem.  2004,  69,  7552-7557.

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138. Liu, X. and J. F. Hartwig Palladium-Catalyzed a-Arylation of Trimethylsilyl Enolates of Esters and Imides. High Functional Group Tolerance and Stereoselective Synthesis of a-Aryl Carboxylic Acid Derivatives. J. Am. Chem. Soc.  2004,  126,  5182-5191.

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127. Culkin, D. A. and J. F. Hartwig Palladium-catalyzed alpha-arylation of carbonyl compounds and nitriles. Acc. Chem. Res.  2003,  36,  234-245.

126. Hama, T., Liu, X., Culkin, D. A., and J. F. Hartwig Palladium-Catalyzed a-Arylation of Esters and Amides under More Neutral Conditions. J. Am. Chem. Soc.  2003,  125,  11176-11177.

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115. Roy, A. H. and J. F. Hartwig Oxidative Addition of Aryl Tosylates to Palladium(0) and Coupling of Unactivated Aryl Tosylates at Room Temperature. J. Am. Chem. Soc.  2003,  125,  8704-8705.

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103. Beare, N. A. and J. F. Hartwig Palladium-catalyzed arylation of malonates and cyanoesters using sterically hindered trialkyl- and ferrocenyldialkylphosphine ligands. J. Org. Chem.  2002,  67,  541-555.

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102. Culkin, D. A. and J. F. Hartwig Synthesis, characterization, and reactivity of arylpalladium cyanoalkyl complexes: Selection of catalysts for the alpha-arylation of nitriles. J. Am. Chem. Soc.  2002,  124,  9330-9331.

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98. Jorgensen, M., Lee, S., Liu, X., Wolkowski, J. P., and J. F. Hartwig Efficient synthesis of a-aryl esters by room-temperature palladium-catalyzed coupling of aryl halides with ester enolates. J. Am. Chem. Soc.  2002,  124,  12557-12565.

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97. Kataoka, N., Shelby, Q., Stambuli, J. P., and J. F. Hartwig Air stable, sterically hindered ferrocenyl dialkylphosphines for palladium-catalyzed C-C, C-N, and C-O bond-forming cross-couplings. J. Org. Chem.  2002,  67,  5553-5566.

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88. Stambuli, J. P., Kuwano, R., and J. F. Hartwig Unparalleled rates for the activation of aryl chlorides and bromides: Coupling with amines and boronic acids in minutes at room temperature. Angew. Chem. Int. Ed.  2002,  41,  4746-4748.

85. Wolkowski, J. P. and J. F. Hartwig Generation of Reactivity from Typically Stable Ligands: C-C Bond-Forming Reductive Elimination from Aryl Palladium(II) Complexes of Malonate Anions. Angew. Chem. Int. Ed.  2002,  114,  4465-4467.

82. Culkin, D. A. and J. F. Hartwig C-C bond-forming reductive elimination of ketones, esters, and amides from isolated arylpalladium(II) enolates. J. Am. Chem. Soc.  2001,  123,  5816-5817.

78. Lee, S., Beare, N. A., and J. F. Hartwig Palladium-catalyzed alpha-arylation of esters and protected amino acids. J. Am. Chem. Soc.  2001,  123,  8410-8411.

76. Lee, S. and J. F. Hartwig Improved catalysts for the palladium-catalyzed synthesis of oxindoles by amide a-arylation. Rate acceleration, use of aryl chloride substrates, and a new carbene ligand for asymmetric transformations. J. Org. Chem.  2001,  66,  3402-3415.

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73. Stambuli, J. P., Stauffer, S. R., Shaughnessy, K. H., and J. F. Hartwig Screening of homogeneous catalysts by fluorescence resonance energy transfer. Identification of catalysts for room-temperature Heck reactions. J. Am. Chem. Soc.  2001,  123,  2677-2678.

72. Stauffer, S. R., Beare, N .A., Stambuli, J. P., and J. F. Hartwig Palladium-catalyzed arylation of ethyl cyanoacetate. Fluorescence resonance energy transfer as a tool for reaction discovery. J. Am. Chem. Soc.  2001,  123,  4641-4642.

56. Kawatsura, M. and J. F. Hartwig Simple, highly active palladium catalysts for ketone and malonate arylation: Dissecting the importance of chelation and steric hindrance. J. Am. Chem. Soc.  1999,  121,  1473-1478.

53. Shaughnessy, K. H., Kim, P., and J. F. Hartwig A fluorescence-based assay for high-throughput screening of coupling reactions. Application to Heck chemistry. J. Am. Chem. Soc.  1999,  121,  2123-2132.

40. Shaughnessy, K. H., Hamann, B. C., and J. F. Hartwig Palladium-catalyzed inter- and intramolecular alpha-arylation of amides. Application of intramolecular amide arylation to the synthesis of oxindoles. J. Org. Chem.  1998,  63,  6546-6553.

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35. Hamann, B. C. and J. F. Hartwig Palladium-catalyzed direct alpha-arylation of ketones. Rate acceleration by sterically hindered chelating ligands and reductive elimination from a transition metal enolate complex. J. Am. Chem. Soc.  1997,  119,  12382-12383.