Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate

The difluoromethylation of phenols with a simple, non-ozone-depleting reagent is described. The reaction occurs within minutes at room temperature with exceptional functional-group tolerance, which makes possible tandem processes for the conversion of arylboronic acids, aryl halides, and arenes to difluoromethyl ethers. Read more on publisher's site.