Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate
Angew. Chem. Int. Ed., 2013, 52 (1–5)
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Abstract
The difluoromethylation of phenols with a simple, non-ozone-depleting reagent is described. The reaction occurs within minutes at room temperature with exceptional functional-group tolerance, which makes possible tandem processes for the conversion of arylboronic acids, aryl halides, and arenes to difluoromethyl ethers.
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