Our research group aims to discover, develop and understand new transition metal-catalyzed reactions. The discovery of fundamentally new transition metal chemistry and its development into practical, catalytic synthetic methods is a theme of our research.


July 2021: Prof. Erik Romero will begin his new position as an Assistant Professor of Chemistry and Biochemistry at University of California, San Diego, CA.

May 2021: Prof. Yang Gu will begin his new position as an Associate Professor at Shenzhen Institute of Advanced Techonolgy, Chinese Academy of Sciences, P.R. China.

February 2021: The lab celebrates Black History Month by highlighting specific Black chemists and their accomplishments. Check out our presentations here.

January 2021: Dr. Pengfei Ji will begin his new position as a Professor in the Department of Chemistry at Zhejiang University, China.

January 2021: Dr. Zhennan Liu will begin her new position as a Research Scientist at the Institute of Chemical and Engineering Sciences, Singapore.

October 2020: Prof. John F. Hartwig won the 2021 Arthur C. Cope Award.

October 2020: Dr. Adrian Tlahuext Aca will begin his new position as a Senior Scientist at Corteva Agriscience in Indianapolis, IN.


Bloomer, B.J.; Clark, D.S.; Hartwig, J.F. Progress, Challenges, and Opportunities with Artificial Metalloenzymes in Biosynthesis. Biochem.  202261,  ASAP.
Ma, S.; Xi, Y.; Fan, H.; Roediger, S.; Hartwig, J.F. Enantioselective hydroamination of unactivated terminal alkenes. Chem  20228,  535-542.
Hanna, S.; Bloomer, B.; Ciccia, N.R.; Butcher, T.W.; Conk, R.J.; Hartwig, J.F. Contra-thermodynamic Olefin Isomerization by Chain-Walking Hydroboration and Dehydroboration. Org. Lett.  202224,  1005-1010.
Liu, Z.; Huang, J.; Gu, Y.; Clark, D.S.; Mukhopadhyay, A.; Keasling, J.D.; Hartwig, J.F. Assembly and Evolution of Artificial Metalloenzymes within E. coli Nissle 1917 for Enantioselective and Site-Selective Functionalization of C-H and C = C Bonds. J. Am. Chem. Soc.  2022144,  883-890.
Gu, Y.; Bloomer, B.J.; Liu, Z.’ Chen, R.: Clark, D.S.; Hartwig, J.F. Directed Evolution of Artificial Metalloenzymes in Whole Cells. Angew. Chem. Int. Ed.  202261,  ASAP.
Su, B.; Hartwig, J.F. Development of Chiral Ligands for the Transition-Metal-Catalyzed Enantioselective Silylation and Borylation of C−H Bonds. Angew. Chem. Int. Ed.  202261,  ASAP.
Butcher, T.W.; Amberg, W.M.; Hartwig, J.F. Transition-Metal-Catalyzed Monofluoroalkylation: Strategies for the Synthesis of Alkyl Fluorides by C-C Bond Formation. Angew. Chem. Int. Ed.  202160,  ASAP.