OUR CHEMISTRY

Our research group aims to discover, develop and understand new transition metal-catalyzed reactions. The discovery of fundamentally new transition metal chemistry and its development into practical, catalytic synthetic methods is a theme of our research.

NEWS & EVENTS



March 2020: Dr. Sean Natoli will begin his new position as a Research Scientist at Procter and Gamble Company in Cincinnati, OH.

February 20, 2020: Cambridge Merck Lectureship at University of Cambridge, England.

February 18 - 19, 2020: British Scientific Society (SCI) Conference at University of Machester, England.

February 2020: Dr. Noam Saper will begin his new position as a Senior Research Chemist at Exemplify BioPharmat in New Jersey.

January 2020: Dr. Zhi-Tao He will begin his new position as a Professor at Shanghai Institute of Organic Chemistry in Shanghai, China.

January 2020: Dr. Yumeng Xi will begin his new position as a Postdoctoral Scholar at University of California Santa Barbara.

March 2019: Dr. Xingyu Jiang will begin his new position as a Senior Scientist at Pharmacyclics, an AbbVie company.

December 2018: Dr. Mingshuo Zeng will begin her new position as a Senior Scientist in the Department of Discovery Chemistry at Genentech, South San Francisco, CA.

June 2018: Dr. Taegyo Lee will begin his new position as a Senior Scientist at Pfizer Inc., Groton, CT.

April 2018: Dr. Eunhye Kang will begin her new position as a Scientist at LG in South Korea.

RECENT PUBLICATIONS

Hanna, S.; Wills, T.; Butcher, T.W.; Hartwig, J.F. Palladium-Catalyzed Oxidative Dehydrosilylation for Contra-Thermodynamic Olefin Isomerization. ACS Catal.  202010,  8736-8741.
Butcher, T.W.; Yang, J.L.; Amberg, W.M.; Watkins, N.B.; Wilkinson, N.D.; Hartwig, J.F. Desymmetrization of difluoromethylene groups by C-F bond activation. Nature  2020583,  548-553.
Karmel, C.; Hartwig, J.F. Mechanism of the iridium-catalyzed silylation of aromatic C-H bonds. J. Am. Chem. Soc.  2020142,  10494-10505.
Buchwald, S.L.; Hartwig, J.F. In Praise of Basic Research as a Vehicle to Practical Applications: Palladium-Catalyzed Coupling to Form Carbon-Nitrogen Bonds. Isr. J. Chem.   202060,  177-179.
Su, B; Bunescu, A.; Qiu, Y.; Zuend, S.J.; Ernst, M.; Hartwig, J.F. Palladium-Catalyzed Oxidation of C(sp3)H Bonds of Primary Alkylamines through a Rare Four-Membered Palladacycle Intermediate. J. Am. Chem. Soc.  2020142,  7912-7919.
Saper, N.I.; Ohgi, A.; Small, D.W.; Semba, K.; Nakao, Y.; Hartwig, J.F. Nickel-catalyzed anti-Markovnikov hydroarylation of unactivated alkenes with unactivated arenes facilitated by non-covalent interactions. Nat. Chem.  202012,  276-283.
Larsen, M.A.; Oeschger, R.J.; Hartwig, J.F. Effect of Ligand Structure on the Electron Density and Activity of Iridium Catalysts for the Borylation of Alkanes. ACS Catal.  202010,  3415-3424.
Dorel, R.; Boehm, P.; Schwinger, D.P.; Hartwig, J.F. Copper-Mediated Fluorination of Aryl Trisiloxanes with Nucleophilic Fluoride. Chem. Eur. J.  202026,  1759-1762.
Yoritate, M.; Londregan, A.T.; Lian, Y.; Hartwig, J.F. Sequential Xanthalation and O‑Trifluoromethylation of Phenols: A Procedure for the Synthesis of Aryl Trifluoromethyl Ethers. J. Org. Chem.  201984,  15767-15776.
Karmel, C.; Rubel, C.Z.; Kharitonova, E.V.; Hartwig, J.F. Iridium‐Catalyzed Silylation of Five‐Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl‐Imidazoline Ligand. Angew. Chem. Int. Ed.  202059,  6074-6081.