OUR CHEMISTRY

Our research group aims to discover, develop and understand new transition metal-catalyzed reactions. The discovery of fundamentally new transition metal chemistry and its development into practical, catalytic synthetic methods is a theme of our research.

NEWS & EVENTS



February 20, 2020: Cambridge Merck Lectureship at University of Cambridge, England.

February 18 - 19, 2020: British Scientific Society (SCI) Conference at University of Machester, England.

January 2020: Dr. Zhi-Tao He will begin his new position as a Professor at Shanghai Institute of Organic Chemistry in Shanghai, China.

January 2020: Dr. Yumeng Xi will begin his new position as a Postdoctoral Scholar at University of California Santa Barbara.

March 2019: Dr. Xingyu Jiang will begin his new position as a Senior Scientist at Pharmacyclics, an AbbVie company.

December 2018: Dr. Mingshuo Zeng will begin her new position as a Senior Scientist in the Department of Discovery Chemistry at Genentech, South San Francisco, CA.

June 2018: Dr. Taegyo Lee will begin his new position as a Senior Scientist at Pfizer Inc., Groton, CT.

April 2018: Dr. Eunhye Kang will begin her new position as a Scientist at LG in South Korea.

April 2018: Dr. Haoquan Li will begin his new position as a Senior Scientist at Dow Chemical Company, Midland, MI.

April 2018: Dr. Ala Bunescu will begin her new position as a Postdoctoral Fellow at Dept. of Chemistry, University of Cambridge, United Kingdom.

RECENT PUBLICATIONS

Karmel, C.; Rubel, C.Z.; Kharitonova, E.V.; Hartwig, J.F. Iridium-catalyzed silylation of five-membered heteroarenes: high sterically derived selectivity from a pyridyl-imidazoline ligand. ChemRxiv   2019None,  1-10.
Oeschger, R.J.; Larsen, M.A.; Bismuto, A.; Hartwig, J.F. Origin of the Difference in Reactivity between Ir Catalysts for the Borylation of C-H Bonds. J. Am. Chem. Soc.  2019141,  16479-16485.
He, Z.; Hartwig, J.F. Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds. Nat. Comm.  201910,  1-4.
Kalkman, E.D.; Mormino, M.G.; Hartwig, J.F. Unusual Electronic Effects of Ancillary Ligands on the Perfluoroalkylation of Aryl Iodides and Bromides Mediated by Copper(I) Pentafluoroethyl Complexes of Substituted Bipyridines. J. Am. Chem. Soc.  2019141,  19458-19465.
Hartwig, J.F.; Ward, T.R. New ‘Cats’ in the House: Chemistry Meets Biology in Artificial Metalloenzymes and Repurposed Metalloenzymes. Acc. Chem. Res.  201952,  1145-1145.
Hanna, S., Butcher, T.W., Hartwig, J.F. Contra-thermodynamic Olefin Isomerization by Chain-Walking Hydrofunctionalization and Formal Retro-hydrofunctionalization. Org. Lett.  201921,  7129-7133.
Gu, Y., Natoli, S.N., Liu, Z., Clark, D.S., Hartwig, J.F. Site-Selective Functionalization of (sp3)C-H Bonds Catalyzed by Artificial Metalloenzymes Containing an Iridium-Porphyrin Cofactor. Angew. Chem. Int. Ed.  201958,  13954-13960.
He, Z.T., Jiang, X., Hartwig, J.F. Stereodivergent Construction of Tertiary Fluorides in Vicinal Stereogenic Pairs by Allylic Substitution with Iridium and Copper Catalysts. J. Am. Chem. Soc.  2019141,  13066-13073.
He, Z.T., Hartwig, J.F. Palladium-Catalyzed α-Arylation of Carboxylic Acids and Secondary Amides via a Traceless Protecting Strategy. J. Am. Chem. Soc.  2019141,  11749-11753.
Hartwig, J.F., Romero, E.A. Iridium-catalyzed silylation of unactivated C-H bonds. Tetrahedron  201975,  4059-4070.