OUR CHEMISTRY

Our research group aims to discover, develop and understand new transition metal-catalyzed reactions. The discovery of fundamentally new transition metal chemistry and its development into practical, catalytic synthetic methods is a theme of our research.

NEWS & EVENTS



February 2021: The lab celebrates Black History Month by highlighting specific Black chemists and their accomplishments. Check out our presentations here.

January 2021: Dr. Pengfei Ji will begin his new position as a Professor in the Department of Chemistry at Zhejiang University, China.

January 2021: Dr. Zhennan Liu will begin her new position as a Research Scientist at the Institute of Chemical and Engineering Sciences, Singapore.

October 2020: Prof. John F. Hartwig won the 2021 Arthur C. Cope Award.

October 2020: Dr. Adrian Tlahuext Aca will begin his new position as a Senior Scientist at Corteva Agriscience in Indianapolis, IN.

October 2020: Dr. Jean-Denys Hamel will begin his new position as an Assistant Professor in the Department of Chemistry and Biochemistry at University of of Lethbridge, Canada.

September 2020: Dr. Liye Chen will begin his new position as a Postdoctoral Scholar in the Department of Cellular Molecular Pharmacology at University of California San Francisco, CA.

September 2020: Dr. Caleb Karmel will begin his new position as a Postdoctoral Scholar at Cardiovascular Research Inst., School of Medicine, University of California San Francisco.

May 2020: Dr. Justin Wang will begin his new position as a Senior Scientist at Chevron Corporation, Richmond, CA.

May 2020: Dr. Bo Su will begin his new position as a Professor in the Department of Chemistry at Nankai University, China.

RECENT PUBLICATIONS

Chen, L.; Malollari, K.G.; Uliana, A.; Sanchez, D.; Messersmith, P.B.; Hartwig, J.F. Selective, Catalytic Oxidations of C-H Bonds in Polyethylenes Produce Functional Materials with Enhanced Adhesion. Chem  20217,  137-145.
Tlahuext-Aca, A.; Lee, S. Y.; Sakamoto, S.; Hartwig, J.F. Direct Arylation of Simple Arenes with Aryl Bromides by Synergistic Silver and Palladium Catalysis. ACS Catal.  202111,  1430-1434.
Tlahuext-Aca, A.; Hartwig, J.F. Site-Selective Silver-Catalyzed C-H Bond Deuteration of Five-Membered Aromatic Heterocycles and Pharmaceuticals. ACS Catal.  202111,  1119-1127.
Ma, S.; Hill, C.K.; Olen, C.L.; Hartwig, J.F. Ruthenium-Catalyzed Hydroamination of Unactivated Terminal Alkenes with Stoichiometric Amounts of Alkene and an Ammonia Surrogate by Sequential Oxidation and Reduction. J. Am. Chem. Soc.  2021143,  359-368.
Xi, Y.; Ma, S.; Hartwig, J.F. Catalytic asymmetric addition of an amine N-H bond across internal alkenes. Nature  2020588,  254-260.
Qiu, Y.; Hartwig, J.F. Mechanism of Ni-Catalyzed Oxidations of Unactivated C(sp3)-H Bonds. J. Am. Chem. Soc.  2020142,  19239-19248.
Wang, J.Y.; Choi, K.; Zuend, S.J.; Borate, K.; Hartwig, J.F. Cross-Coupling between Hydrazine and Aryl Halides with Hydroxide Base at Low Loadings of Palladium by Rate-Determining Deprotonation of Bound Hydrazine. Angew. Chem. Int. Ed.  202059,  1-2.
Oeschger, R.; Su, B.; Yu, I.; Ehinger, C.; Romero, E.; He, S.; Hartwig, J.F. Diverse functionalization of strong alkyl C–H bonds by undirected borylation. Science  2020368,  736-741.
Hartwig, J.F.; Shaughnessy, K.H.; Shekhar, S.; Green, R.A. Palladium-Catalyzed Amination of Aryl Halides. Organic Reactions  2020100,  853-943.
Xi, Y.; Su, B.; Qi, X.; Pedram, S.; Liu, P.; Hartwig, J.F. Application of Trimethylgermanyl-Substituted Bisphosphine Ligands with Enhanced Dispersion Interactions to Copper-Catalyzed Hydroboration of Disubstituted Alkenes. J. Am. Chem. Soc.  2020142,  18213-18222.