Publications

450. Kalkman, E. D.; Hartwig, J. F. Direct Observation of Diastereomeric α-C-Bound Enolates during Enantioselective α-Arylations: Synthesis, Characterization, and Reactivity of Arylpalladium Fluorooxindole Complexes. J. Am. Chem. Soc. 2021, 143, 11741-11750.

417. He, Z.; Hartwig, J.F. Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds. Nat. Comm. 2019, 10, 1-4.

366. Jiao, Z.; Beiger, J.J.; Jin, Y.; Ge, S.; Zhou, J.; Hartwig, J.F. Palladium-Catalyzed Enantioselective α-Arylation of α-Fluoroketones. J. Am. Chem. Soc. 2016, 138, 15980–15986.

348. Arlow, S.I.; Hartwig, J.F. Synthesis of Aryldifluoroamides by Copper-Catalyzed Cross-Coupling. Angew. Chem. Int. Ed. 2016, 55, 4567-4572.

329. Ge, S.; Arlow, S.I.; Mormino, M.G.; Hartwig, J.F. Pd-Catalyzed α‑Arylation of Trimethylsilyl Enolates of α,α-Difluoroacetamides. J. Am. Chem. Soc. 2014, 136, 14401-14404.

317. Mormino, M.G.; Fier, P.S.; Hartwig, J.F. Copper-Mediated Perfluoroalkylation of Heteroaryl Bromides with (phen)CuRF. Org. Lett. 2014, 16, 1744-1747.

314. Ge, S.; Chaładaj, W.; Hartwig, J.F. Pd-Catalyzed α‐Arylation of α,α-Difluoroketones with Aryl Bromides and Chlorides. A Route to Difluoromethylarenes. J. Am. Chem. Soc. 2014, 136, 4149-4152.

307. Hama, T.; Ge, S.; Hartwig, J.F. Palladium-Catalyzed α-Arylation of Zinc Enolates of Esters: Reaction Conditions and Substrate Scope. J. Org. Chem. 2013, 78, 8250-8266.

303. Gallego, D.; Brück, A.; Irran, E.; Meier, F.; Kaupp, M.; Driess, M.; Hartwig, J.F. From Bis(silylene) and Bis(germylene) Pincer-Type Nickel(II) Complexes to Isolable Intermediates of the Nickel-Catalyzed Sonogashira Cross-Coupling Reaction. J. Am. Chem. Soc. 2013, 135, 15617-15626.

289. Fier, P.S.; Hartwig, J.F. Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate. Angew. Chem. Int. Ed. 2013, 52, 1–5.

288. Ge, S.; Hartwig, J.F. Highly Reactive, Single-Component Nickel Catalyst Precursor for Suzuki-Miyuara Cross-Coupling of Heteroaryl Boronic Acids with Heteroaryl Halides. Angew. Chem. Int. Ed. 2012, 51, 12837–12841.

278. Fier, P.S.; Hartwig, J.F. Copper Mediated Difluoromethylation of Aryl and Vinyl Iodides. J. Am. Chem. Soc. 2012, 134, 5524–5527.

275. Klinkenberg, J.L.; Hartwig, J.F. Reductive Elimination from Arylpalladium Cyanide Complexes. J. Am. Chem. Soc. 2012, 134, 5758–5761.

272. Huang, Z.; Hartwig, J.F. Copper(I) Enolate Complexes in Alpha-Arylation Reactions: Synthesis, Reactivity, and Mechanism. Angew. Chem. Int. Ed. 2012, 51, 1028–1032.

265. Ge, S.; Hartwig, J.F. Nickel-catalyzed Asymmetric α-Arylation and Heteroarylation of Ketones with Chloroarenes: Effect of Halide on Selectivity, Oxidation State and Room Temperature Reactions. J. Am. Chem. Soc 2011, 133, 16330-16333.

261. Carrow, B. P.; Hartwig, J. F. Distinguishing Between Pathways for Transmetalation in Suzuki-Miyaura Reactions. J. Am. Chem. Soc 2011, 133, 2116-2119.

260. Huang, D.S.; DeLuca, R. J.; Hartwig, J.F. α-Arylation of Esters Catalyzed by the Pd(I) Dimer [P(t-Bu)₃]Pd(m-Br)]₂. Org. Synth. 2011, 88, 4-13.

259. Liao, X.; Stanley, L.M.; Hartwig, J.F. Enantioselective Total Syntheses of (−)-Taiwaniaquinone H and (−)-Taiwaniaquinol B by Iridium-Catalyzed Borylation and Palladium-Catalyzed Asymmetric α-Arylation. J. Am. Chem. Soc. 2011, 133, 2088-2091.

251. Huang, D.S.; Hartwig, J.F. Palladium-Catalyzed γ-Arylation of α,β-Unsaturated Esters from Silyl Ketene Acetals. Angew. Chem. Int. Ed. 2010, 49, 5757-5761 (designated as a "Hot Paper").

236. Carrow, B.P.; Hartwig, J.F. Ligandless, Anionic, Arylpalladium Halide Intermediates in the Heck Reaction. J. Am. Chem. Soc. 2009, 132, 79-81.

226. Barrios-Landeros, F.; Carrow, B.P.; Hartwig, J.F Effect of Ligand Steric Properties and Halide Identity on the Mechanism for Oxidative Addition of Haloarenes to Trialkylphosphine Pd(0) Complexes. J. Am. Chem. Soc. 2009, 131, 8141-8154.

217. Alexanian, E.J.; Hartwig, J.F. Mechanistic Study of β-Hydrogen Elimination from Organoplatinum(II) Enolate Complexes. J. Am. Chem. Soc. 2008, 130, 15627-15635.

211. Liao, X., Weng, Z., and J. F. Hartwig Enantioselective-Arylation of Ketones with Aryl Triflates Catalyzed by Difluorphos Complexes of Palladium and Nickel. J. Am. Chem. Soc. 2008, 130, 195-200.

208. Vo, G.D., and J.F. Hartwig Palladium-Catalyzed α-Arylation of Aldehydes with Bromo- and Chloroarenes Catalyzed by [Pd(allyl)Cl]₂ and DPPF or Q-phos.. Angew. Chem. Int. Ed. 2008, 47, 2127-2130.

206. Barrios-Landeros, F., Carrow, B.P., and J.F. Hartwig Autocatalytic Oxidative Addition of PhBr to Pd(PtBu₃)₂ via Pd(PtBu3)2(H)(Br).. J. Am. Chem. Soc. 2008, 130, 5842-5843.

204. Hama, T.; Hartwig, J.F. Palladium-Catalyzed a-Arylation of Esters with Chloroarenes.. Org. Lett. 2008, 10, 1549-1552.

203. Hama, T., and J.F. Hartwig a-Arylation of Esters Catalyzed by the Pd(I) Dimer {[P(t-Bu)₃]PdBr}₂.. Org. Lett. 2008, 10, 1545-1548.

183. Takemiya, A., and J. F. Hartwig Palladium-Catalyzed Synthesis of Aryl Ketones by Coupling of Aryl Bromides with an Acyl Anion Equivalent. J. Am. Chem. Soc. 2006, 128, 14800-14801.

178. Su, W.; Raders, S.; Verkade, J.G.; Liao, X; Hartwig, J.F. Palladium-Catalyzed alpha-Arylation of Trimethylsilyl Enol Ethers with Aryl Bromides and Chlorides. A Synergistic Effect of Two Metal Fluorides as Additives. Angew. Chem. Int. Ed. 2006, 45, 5852-5855.

170. Hama, T., Culkin, D. A., and J. F. Hartwig Palladium-Catalyzed Intermolecular a-Arylation of Zinc Amide Enolates under Mild Conditions. J. Am. Chem. Soc. 2006, 128, 4976-4985.

155. Limmert, M. E., Roy, A. H., and J. F. Hartwig Kumada Coupling of Aryl and Vinyl Tosylates under Mild Conditions. J. Org. Chem. 2005, 127, 9364-9370.

151. Wu, L. and J. F. Hartwig Mild Palladium-Catalyzed Selective Monoarylation of Nitriles. J. Am. Chem. Soc. 2005, 127, 15824-15832.

144. Culkin, D. A. and J. F. Hartwig Carbon-Carbon Bond-Forming Reductive Elimination from Arylpalladium Complexes Containing Functionalized Alkyl Groups. Influence of Ligand Steric and Electronic Properties on Structure, Stability, and Reactivity. Organometallics 2004, 23, 3398-3416.

140. Leitner, A., Larsen, J., Steffens, C. and J. F. Hartwig Palladium-Catalyzed Addition of Mono- and Dicarbonyl Compounds to Conjugated Dienes. J. Org. Chem. 2004, 69, 7552-7557.

138. Liu, X. and J. F. Hartwig Palladium-Catalyzed a-Arylation of Trimethylsilyl Enolates of Esters and Imides. High Functional Group Tolerance and Stereoselective Synthesis of a-Aryl Carboxylic Acid Derivatives. J. Am. Chem. Soc. 2004, 126, 5182-5191.

137. Roy, A. H. and J. F. Hartwig Oxidative Addition of Aryl Sulfonates to Palladium(0) Complexes of Mono- and Bidentate Phosphines. Mild Addition of Aryl Tosylates and the Effects of Anions on Rate and Mechanism. Organometallics 2004, 23, 194-202.

136. Roy, A. H. and J. F. Hartwig Reductive Elimination of Aryl Halides upon Addition of Hindered Alkylphosphines to Dimeric Arylpalladium(II) Halide Complexes. Organometallics 2004, 23, 1533-1541.

132. Stambuli, J. P., Incarvito, C. D., Buhl, M. and J. F. Hartwig Synthesis, Structure, Theoretical Studies, and Ligand Exchange Reactions of Monomeric, T-Shaped Arylpalladium(II) Halide Complexes with an Additional, Weak Agostic Interaction. J. Am. Chem. Soc. 2004, 126, 1184-1194.

130. Yamashita, M. and J. F. Hartwig Synthesis, Structure, and Reductive Elimination Chemistry of Three-Coordinate Arylpalladium Amido Complexes. J. Am. Chem. Soc. 2004, 126, 5344-5345.

127. Culkin, D. A. and J. F. Hartwig Palladium-catalyzed alpha-arylation of carbonyl compounds and nitriles. Acc. Chem. Res. 2003, 36, 234-245.

126. Hama, T., Liu, X., Culkin, D. A., and J. F. Hartwig Palladium-Catalyzed a-Arylation of Esters and Amides under More Neutral Conditions. J. Am. Chem. Soc. 2003, 125, 11176-11177.

119. Liu, X. and J. F. Hartwig Palladium-catalyzed a-arylation of azlactones to form quaternary amino acid derivatives.. Org. Lett. 2003, 5, 1915-1918.

115. Roy, A. H. and J. F. Hartwig Oxidative Addition of Aryl Tosylates to Palladium(0) and Coupling of Unactivated Aryl Tosylates at Room Temperature. J. Am. Chem. Soc. 2003, 125, 8704-8705.

103. Beare, N. A. and J. F. Hartwig Palladium-catalyzed arylation of malonates and cyanoesters using sterically hindered trialkyl- and ferrocenyldialkylphosphine ligands. J. Org. Chem. 2002, 67, 541-555.

102. Culkin, D. A. and J. F. Hartwig Synthesis, characterization, and reactivity of arylpalladium cyanoalkyl complexes: Selection of catalysts for the alpha-arylation of nitriles. J. Am. Chem. Soc. 2002, 124, 9330-9331.

98. Jorgensen, M., Lee, S., Liu, X., Wolkowski, J. P., and J. F. Hartwig Efficient synthesis of a-aryl esters by room-temperature palladium-catalyzed coupling of aryl halides with ester enolates. J. Am. Chem. Soc. 2002, 124, 12557-12565.

97. Kataoka, N., Shelby, Q., Stambuli, J. P., and J. F. Hartwig Air stable, sterically hindered ferrocenyl dialkylphosphines for palladium-catalyzed C-C, C-N, and C-O bond-forming cross-couplings. J. Org. Chem. 2002, 67, 5553-5566.

88. Stambuli, J. P., Kuwano, R., and J. F. Hartwig Unparalleled rates for the activation of aryl chlorides and bromides: Coupling with amines and boronic acids in minutes at room temperature. Angew. Chem. Int. Ed. 2002, 41, 4746-4748.

85. Wolkowski, J. P. and J. F. Hartwig Generation of Reactivity from Typically Stable Ligands: C-C Bond-Forming Reductive Elimination from Aryl Palladium(II) Complexes of Malonate Anions. Angew. Chem. Int. Ed. 2002, 114, 4465-4467.

82. Culkin, D. A. and J. F. Hartwig C-C bond-forming reductive elimination of ketones, esters, and amides from isolated arylpalladium(II) enolates. J. Am. Chem. Soc. 2001, 123, 5816-5817.

78. Lee, S., Beare, N. A., and J. F. Hartwig Palladium-catalyzed alpha-arylation of esters and protected amino acids. J. Am. Chem. Soc. 2001, 123, 8410-8411.

76. Lee, S. and J. F. Hartwig Improved catalysts for the palladium-catalyzed synthesis of oxindoles by amide a-arylation. Rate acceleration, use of aryl chloride substrates, and a new carbene ligand for asymmetric transformations. J. Org. Chem. 2001, 66, 3402-3415.

73. Stambuli, J. P., Stauffer, S. R., Shaughnessy, K. H., and J. F. Hartwig Screening of homogeneous catalysts by fluorescence resonance energy transfer. Identification of catalysts for room-temperature Heck reactions. J. Am. Chem. Soc. 2001, 123, 2677-2678.

72. Stauffer, S. R., Beare, N .A., Stambuli, J. P., and J. F. Hartwig Palladium-catalyzed arylation of ethyl cyanoacetate. Fluorescence resonance energy transfer as a tool for reaction discovery. J. Am. Chem. Soc. 2001, 123, 4641-4642.

56. Kawatsura, M. and J. F. Hartwig Simple, highly active palladium catalysts for ketone and malonate arylation: Dissecting the importance of chelation and steric hindrance. J. Am. Chem. Soc. 1999, 121, 1473-1478.

53. Shaughnessy, K. H., Kim, P., and J. F. Hartwig A fluorescence-based assay for high-throughput screening of coupling reactions. Application to Heck chemistry. J. Am. Chem. Soc. 1999, 121, 2123-2132.

40. Shaughnessy, K. H., Hamann, B. C., and J. F. Hartwig Palladium-catalyzed inter- and intramolecular alpha-arylation of amides. Application of intramolecular amide arylation to the synthesis of oxindoles. J. Org. Chem. 1998, 63, 6546-6553.

35. Hamann, B. C. and J. F. Hartwig Palladium-catalyzed direct alpha-arylation of ketones. Rate acceleration by sterically hindered chelating ligands and reductive elimination from a transition metal enolate complex. J. Am. Chem. Soc. 1997, 119, 12382-12383.