Publications

C-C Bond Forming Cross-Couplings C-X Bond Forming Cross-Couplings Olefin Functionalization Iridium-Catalyzed Allylic Substitution C-H Bond Functionalization Catalysis for Sustainable Energy & Polymers Fluorination and Fluoroalkylation Main-Group-Transition Metal Organometallics New Organometallic Reactions High Throughput Screening Combining Organometallics with Biocatalysis Reviews Commentary and Book Chapters
C-H Borylation C-H Silylation Other C-H Functionalization
437. Oeschger, R.; Su, B.; Yu, I.; Ehinger, C.; Romero, E.; He, S.; Hartwig, J.F. Diverse functionalization of strong alkyl C–H bonds by undirected borylation. Science  2020,  368,  736-741.

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423. Larsen, M.A.; Oeschger, R.J.; Hartwig, J.F. Effect of Ligand Structure on the Electron Density and Activity of Iridium Catalysts for the Borylation of Alkanes. ACS Catal.  2020,  10,  3415-3424.

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418. Oeschger, R.J.; Larsen, M.A.; Bismuto, A.; Hartwig, J.F. Origin of the Difference in Reactivity between Ir Catalysts for the Borylation of C-H Bonds. J. Am. Chem. Soc.  2019,  141,  16479-16485.

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347. Larsen, M.A.; Cho, S.H.; Hartwig, J.F. Iridium-Catalyzed, Hydrosilyl-Directed Borylation of Unactivated Alkyl C–H Bonds. J. Am. Chem. Soc.  2016,  138,  762-765.

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339. Larsen, M.A.; Wilson, C.V.; Hartwig, J.F. Iridium-Catalyzed Borylation of Primary Benzylic C–H Bonds without a Directing Group: Scope, Mechanism, and Origins of Selectivity. J. Am. Chem. Soc.  2015,  137,  8633-8643.

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319. Li, Q.; Liskey, C.W.; Hartwig, J.F. Regioselective Borylation of the C–H Bonds in Alkylamines and Alkyl Ethers. Observation and Origin of High Reactivity of Primary C–H Bonds Beta to Nitrogen and Oxygen. J. Am. Chem. Soc.  2014,  136,  8755–8765.

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316. Cho, S.H.; Hartwig, J.F. Iridium-catalyzed diborylation of benzylic C–H bonds directed by a hydrosilyl group: synthesis of 1,1-benzyldiboronate esters. Chem. Sci.  2014,  5,  694-698.

315. Larsen, M.A.; Hartwig, J.F. Iridium-Catalyzed C−H Borylation of Heteroarenes: Scope, Regioselectivity, Application to Late-Stage Functionalization, and Mechanism. J. Am. Chem. Soc.  2014,  136,  4287-4299.

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296. Cho, S.H.; Hartwig, J.F. Iridium-Catalyzed Borylation of Secondary Benzylic C–H Bonds Directed by a Hydrosilane. J. Am. Chem. Soc.  2013,  135,  8157–8160.

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295. Liskey, C.W.; Hartwig, J.F. Iridium-Catalyzed C–H Borylation of Cyclopropanes. J. Am. Chem. Soc.  2013,  135,  3375–3378.

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291. Robbins, D.W.; Hartwig, J.F. Sterically Controlled Alkylation of Arenes through Iridium-Catalyzed C-H Borylation. Angew. Chem. Int. Ed.  2013,  52,  933–937.

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290. Partridge, B.M.; Hartwig, J.F. Sterically Controlled Iodination of Arenes via Iridium-Catalyzed C-H Borylation. Org. Lett.  2013,  15,  140–143.

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281. Robbins, D.W.; Hartwig, J.F. A C-H Borylation Approach to Suzuki-Miyaura Coupling of Typically Unstable 2-Heteroaryl and Polyfluorophenyl Boronates. Org. Lett.  2012,  14,  4266–4269.

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280. Liskey, C.W.; Hartwig, J.F. Iridium-Catalyzed Borylation of Secondary C-H Bonds in Cyclic Ethers. J. Am. Chem. Soc.  2012,  134,  12422–12425.

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249. Liskey, C.W.; Xuebin Liao, X.; Hartwig, J.F. Cyanation of Arenes via Iridium-Catalyzed Borylation. J. Am. Chem. Soc.   2010,  132,  11389-11391.

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244. Robbins, D.W.; Boebel, T. A.; Hartwig, J.F. Iridium-Catalyzed, Silyl-Directed Borylation of Nitrogen-Containing Heterocycles. J. Am. Chem. Soc.   2010,  132,  4068-4069.

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241. Sawyer, K.R., Cahoon, J.F., Shanoski, J.E., Glascoe, E.A., Kling, M.F., Schlegel, J.P., Zoerb, M.C., Hapke, M., Hartwig, J.F., Webster, C.E., Harris, C.B. Time-resolved IR Studies on the Mechanism for the Functionalization of Primary C−H Bonds by Photoactivated Cp*W(CO)3(Bpin). J. Am. Chem. Soc.  2010,  132,  1848-1859.

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240. Wei, C.S.; Jiménez-Hoyos, C.A.; Videa, M.F.; Hartwig, J.F.; Hall, M.B. Origins of the Selectivity for Borylation of Primary over Secondary C–H Bonds Catalyzed by Cp*-Rhodium Complexes. J. Am. Chem. Soc.  2010,  132,  3078-3091.

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238. Mkhalid, I.A.I.; Barnard, J.H.; Marder, T.B.; Murphy, J.M.; Hartwig, J.F. C-H Activation for the Construction of C-B Bonds. Chem. Rev.  2010,  110,  890-931.

233. Liskey, C.W., Wei, C.S., Pahls, D.R., Hartwig J.F. Pronounced Effects of Substituents on the Iridium-Catalyzed Borylation of Aryl C–H Bonds. Chem. Commun.  2009,  0,  5603-5605.

220. Boebel, T.A.; Hartwig, J.F. Conversion of 1,3-Disubstituted Arenes to Chiral α,α-Diaryl Methylammonium Chlorides Using Arene Borylation. Tetrahedron  2008,  64,  6824-6830.

202. Boebel, T.A. and J.F. Hartwig Silyl-Directed, Iridium-Catalyzed ortho-Borylation of Arenes. A One-Pot ortho-Borylation of Phenols, Arylamines, and Alkylarenes.. J. Am. Chem. Soc.  2008,  130,  7534-7535.

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200. Murphy, J.M., Liao, X., and J. F. Hartwig Meta Halogenation of 1,3-Disubstituted Arenes via Iridium-Catalyzed Arene Borylation.. J. Am. Chem. Soc.  2007,  129,  15434-15435.

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181. Murphy, J. M., Lawrence, J. D., Kawamura, K., Incarvito, C., and J. F. Hartwig Ruthenium-Catalyzed Regiospecific Borylation of Methyl C-H Bonds. J. Am. Chem. Soc.  2006,  128,  13684-13685.

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162. Boller, T. M., Murphy, J. M., Hapke, M., Ishiyama, T., Miyaura, N., and J. F. Hartwig Mechanism of the Mild Functionalization of Arenes by Diboron Reagents Catalyzed by Iridium Complexes. Intermediacy and Chemistry of Bipyridine-Ligated Iridium Trisboryl Complexes. J. Am. Chem. Soc.  2005,  127,  14263-14278.

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159. Hartwig, J. F., Cook, K. S., Hapke, M., Incarvito, C. D., Fan, Y., Webster, C. E., and M. B. Hall Rhodium Boryl Complexes in the Catalytic, Terminal Functionalization of Alkanes. J. Am. Chem. Soc.  2005,  127,  2538-2552.

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141. Lawrence, J. D., Takahashi, M., Bae, C. and J. F. Hartwig Regiospecific Functionalization of Methyl C-H Bonds of Alkyl Groups in Reagents with Heteroatom Functionality. J. Am. Chem. Soc.  2004,  126,  15334-15335.

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123. Ishiyama, T., Takagi, J., Yonekawa, Y., Hartwig, J. F., and N. Miyaura Iridium-Catalyzed Direct Borylation of Five-Membered Heteroarenes by Bis(pinacolato)diboron: Regioselective, Stoichiometric, and Room Temperature Reactions. Advanced Synthesis and Catalysis  2003,  345,  1103-1106.

122. Ishiyama, T., Nobuta, Y., Hartwig, J. F., and N. Miyaura Room Temperature Borylation of Arenes and Heteroarenes Using Stoichiometric Amounts of Pinacolborane Catalyzed by Iridium Complexes in an Inert Solvent.. Chemical Communications  2003,  23,  2924-2925.

109. Webster, C. E., Fan, Y., Hall, M. B., Kunz, D., and J. F. Hartwig Experimental and Computational Evidence for a Boron-Assisted, Sigma-Bond Metathesis Pathway for Alkane Borylation. J. Am. Chem. Soc.  2003,  125,  858-859.

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100. Ishiyama, T., Takagi, J., Hartwig, J. F., and N. Miyaura A stoichiometric aromatic C-H borylation catalyzed by iridium(I)/2,2 '-bipyridine complexes at room temperature. Angew. Chem. Int. Ed.  2002,  41,  3056-3058.

99. Ishiyama, T., Takagi, J., Ishida, K., Miyaura, N., Anasrasi, N. R., and J. F. Hartwig Mild iridium-catalyzed borylation of arenes. High turnover numbers, room temperature reactions, and isolation of a potential intermediate. J. Am. Chem. Soc.  2002,  124,  390-391.

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96. Kondo, Y., Garcia-Cuadrado, D., Hartwig, J. F., Boaen, N. K., Wagner, N. L. and A. M. Hillmyer Rhodium-catalyzed, regiospecific functionalization of polyolefins in the melt. J. Am. Chem. Soc.  2002,  124,  1164-1165.

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86. Takagi, J., Sato, K., Hartwig, J. F., Ishiyama, T., and N. Miyaura Iridium-catalyzed C-H coupling reaction of heteroaromatic compounds with bis(pinacolato)diboron: regioselective synthesis of heteroarylboronates. Tetrahedron Letters  2002,  43,  5649-5651.

80. Kawamura, K. and J. F. Hartwig Isolated Ir(V) boryl complexes and their reactions with hydrocarbons. J. Am. Chem. Soc.  2001,  123,  8422-8423.

68. Chen, H. Y., Schlecht, S., Semple, T. C., and J. F. Hartwig Thermal, catalytic, regiospecific functionalization of alkanes. Science  2000,  287,  1995-1997.

62. Waltz, K. M. and J. F. Hartwig Functionalization of alkanes by isolated transition metal boryl complexes. J. Am. Chem. Soc.  2000,  122,  11358-11369.

61. Chen, H. Y. and J. F. Hartwig Catalytic, regiospecific end-functionalization of alkanes: Rhenium-catalyzed borylation under photochemical conditions. Angew. Chem. Int. Ed.  1999,  38,  3391-3393.

52. Waltz, K. M., Muhoro, C. N., and J. F. Hartwig C-H activation and functionalization of unsaturated hydrocarbons by transition-metal boryl complexes. Organometallics  1999,  18,  3383-3393.

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28. Waltz, K. M. and J. F. Hartwig Selective functionalization of alkanes by transition-metal boryl complexes. Science  1997,  277,  211-213.

8. Waltz, K.M., He, X., Muhoro, C., and J. F. Hartwig Hydrocarbon Functionalization by Transition-Metal Boryls. J. Am. Chem. Soc.  1995,  117,  11357-11358.