Publications

C-C Bond Forming Cross-Couplings C-X Bond Forming Cross-Couplings Olefin Functionalization Iridium-Catalyzed Allylic Substitution C-H Bond Functionalization Catalysis for Sustainable Energy & Polymers Fluorination and Fluoroalkylation Main-Group-Transition Metal Organometallics New Organometallic Reactions High Throughput Screening Combining Organometallics with Biocatalysis Reviews Commentary and Book Chapters
445. Ji, P.; Park, J.; Gu, Y.; Clark, D.S.; Hartwig, J.F. Abiotic reduction of ketones with silanes catalysed by carbonic anhydrase through an enzymatic zinc hydride. Nat. Chem.  2021,  13,  312-318.

TOC


410. Gu, Y., Natoli, S.N., Liu, Z., Clark, D.S., Hartwig, J.F. Site-Selective Functionalization of (sp3)C-H Bonds Catalyzed by Artificial Metalloenzymes Containing an Iridium-Porphyrin Cofactor. Angew. Chem. Int. Ed.  2019,  58,  13954-13960.

TOC


402. Natoli, S.N., Hartwig, J.F. Noble-Metal Substitution in Hemoproteins: An Emerging Strategy for Abiological Catalysis. Acc. Chem. Res.  2019,  52,  326-335.

TOC


395. Litman, Z.C.; Wang, Y.; Zhao, H.; Hartwig, J.F. Cooperative asymmetric reactions combining photocatalysis and enzymatic catalysis. Nature  2018,  560,  355-359.

TOC


373. Wang, Y.; Bartlett, M.J.; Denard, C.A.; Hartwig, J.F.; Zhao, H. Combining Rh-catalyzed Diazocoupling and Enzymatic Reduction to Efficiently Synthesize Enantioenriched 2-substituted Succinate Derivatives. ACS. Catal.  2017,  7,  2548–2552.

TOC


369. Dydio, P.; Key, H.M.; Hayashi, H.; Clark, D.S.; Hartwig, J.F. Chemoselective, Enzymatic C-H Bond Amination Catalyzed by a Cytochrome P450 Containing an Ir(Me)-PIX Cofactor. J. Am. Chem. Soc.  2017,  139,  1750–1753.

TOC


361. Dydio, P; Key, H.M.; Nazarenko, A.; Rha, J.Y.-E.; Seyedkazemi, V.; Clark, D.S.; Hartwig, J.F. An artificial metalloenzyme with the kinetics of native enzymes. Science  2016,  6308,  102-106.

TOC


352. Key, H.M.; Dydio, P.; Clark, D.S.; Hartwig, J.F. Abiological Catalysis by Artificial Heme Proteins Containing Noble Metals in Place of Iron. Nature  2016,  534,  534-537.

TOC


336. Key, H.M.; Clark, D.S.; Hartwig, J.F. Generation, Characterization, and Tunable Reactivity of Organometallic Fragments Bound to a Protein Ligand. J. Am. Chem. Soc.  2015,  137,  8261-8268.

TOC


334. Denard, C.A.; Bartlett, M.J.; Wang, J.; Lu, L.; Hartwig, J.F.; Zhao, H. Development of a one-pot tandem reaction combining ruthenium-catalyzed alkene metathesis and enantioselective enzymatic oxidation to produce aryl epoxides. ACS Catal.  2015,  5,  3817-3822.

TOC


308. Denard, C.A.; Huang, H.; Bartlett, M.J.; Lu, L.; Tan, Y.; Zhao, H.; Hartwig, J.F. Cooperative Tandem Catalysis by an Organometallic Complex and a Metalloenzyme. Angew. Chem. Int. Ed.  2014,  53,  465-469.

TOC