479. Sterling, A. J.; Ciccia, N. R.; Guo, Y.; Hartwig, J. F.; Head-Gordon, M.
Mechanistic Insights into the Origins of Selectivity in a Cu-Catalyzed C–H Amidation Reaction.
J. Am. Chem. Soc.2024,
146, ASAP.
478. Pierson, C. N.; Hartwig, J. F.
Mapping the Mechanism of Oxidative Addition in Cross-coupling Reactions Catalysed by Phosphine-ligated Ni(0).
Nat. Chem.2024,
None, ASAP.
477. Bloomer, B. J.; Joyner, I. A.; Garcia-Borràs, M.; Hu, D. B.; Garçon, M.; Quest, A.; Ugarte Montero, C.; Yu, I. F.; Clark, D. S.; Hartwig, J. F.
Enantio- and Diastereodivergent Cyclopropanation of Allenes by Directed Evolution of an Iridium-Containing Cytochrome.
J. Am. Chem. Soc.2024,
146, ASAP.
476. Ciccia, N. R.; Shi, J. X.; Pal, S.; Hua, M.; Malollari, K. G.; Lizandara-Pueyo, C.; Risto, E.; Ernst, M.; Helms, B. A.; Messersmith, P. B.; Hartwig, J. F.
Diverse functional polyethylenes by catalytic amination.
Science2023,
381, 1433-1440.
475. Yu, I. F.; Wilson, J. W.; Hartwig, J. F.
Transition-Metal-Catalyzed Silylation and Borylation of C-H Bonds for the Synthesis and Functionalization of Complex Molecules.
Chem. Rev.2023,
123, 11619–11663.
474. Shi, J. X.; Ciccia, N. R.; Pal, S.; Kim, D. D.; Brunn, J. N.; Lizandara-Pueyo, C.; Ernst, M.; Haydl, A. M.; Messersmith, P. B.; Helms, B. A.; Hartwig, J. F.
Chemical Modification of Oxidized Polyethylene Enables Access to Functional Polyethylenes with Greater Reuse.
J. Am. Chem. Soc.2023,
145, 21527-21537.
473. Kalkman, E. D.; Qiu, Y.; Hartwig, J. F.
Transition-State Stabilization by Secondary Orbital Interactions between Fluoroalkyl Ligands and Palladium During Reductive Elimination from Palladium(aryl)(fluoroalkyl) Complexes.
ACS Catal.2023,
13, 12810-12825.
472. Delaney, C. P.; Lin, E.; Huang, Q.; Yu, I. F.; Rao, G.; Tao, L.; Jed, A.; Fantasia, S. M.; Puntener, K. A.; Britt, R. D.; Hartwig, J. F.
Cross-coupling by a noncanonical mechanism involving the addition of aryl halide to Cu(II).
Science2023,
381, 1079-1085.
471. Luo, Y.; Li, Y.; Wu, J.; Xue, X. S.; Hartwig, J. F.; Shen, Q.
Oxidative addition of an alkyl halide to form a stable Cu(III) product.
Science2023,
381, 1072-1079.
470. Wilson, J. W.; Su, B.; Yoritate, M.; Shi, J. X.; Hartwig, J. F.
Iridium-Catalyzed, Site-Selective Silylation of Secondary C(sp3)-H Bonds in Secondary Alcohols and Ketones.
J. Am. Chem. Soc.2023,
145, 19490–19495.
469. Caldeweyher, E.; Elkin, M.; Gheibi, G.; Johansson, M.; Skold, C.; Norrby, P-O, Hartwig, J. F.
Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation.
J. Am. Chem. Soc.2023,
145, 17367–17376.
468. Van Cura, D.; Ng, T.L.; Huang, J.; Hager, H.; Hartwig, J.F.; Keasling, J.D.; Balskus, E.P.
Discovery of the azaserine biosynthetic pathway uncovers a biological route for α-diazoester production.
Angew. Chem. Int. Ed.2023,
62, e202304646.
467. Ma, S.; Fan, H.; Day, C.S.; Xi, Y.; Hartwig, J.F.
Remote Hydroamination of Disubstituted Alkenes by a Combination of Isomerization and Regioselective N-H Addition.
J. Am. Chem. Soc.2023,
145, 3875-3881.
466. Huang, J.; Quest, A.; Cruz-Morales, P.; Deng, K.; Henrique Pereira, J.; Van Cura, D.; Kakumanu, R.; Baidoo, E.E.K.; Dan, Q.; Chen, Y.; Petzold, C.J.; Northen, T.R.; Adams, P.D.; Clark, D.S.; Balskus, E.P.; Hartwig, J.F.; Mukhopadhyay, A.; Keasling, J.D.
Complete integration of carbene transfer chemistry into biosynthesis.
Nature2023,
617, 403–408.
464. Ma, S.; Hartwig, J.F.
Progression of Hydroamination Catalyzed by Late Transition-Metal Complexes from Activated to Unactivated Alkenes.
Acc. Chem. Res.2023,
56, 1565-1577.
463. Bloomer, B.J.; Natoli, S.N.; Garcia-Borras, M.; Pereira, J.H.; Hu, D.B.; Adams, P.D.; Houk, K.N.; Clark, D.S.; Hartwig, J.F.
Mechanistic and structural characterization of an iridium-containing cytochrome reveals kinetically relevant cofactor dynamics.
Nature Catalysis2023,
6, 39-51.
462. Conk, R.J.; Hanna, S.; Shi, J.X.; Yang, J.; Ciccia, N.R.; Qi, L.; Bloomer, B.J.; Heuvel, S.; Wills, T.; Su, J.; Bell, A.T.; Hartwig, J.F.
Catalytic Deconstruction of Waste Polyethylene with Ethylene to Form Propylene.
Science2022,
377, 1561-1566.
461. Choi, K.; Mormino, M.G.; Kalkman, E.D.; Park, J.; Hartwig, J.F.
Palladium-Catalyzed Aryldifluoromethylation of Aryl Halides with Aryldifluoromethyl Trimethylsilanes.
Angew. Chem. Int. Ed.2022,
61, e202208204.
460. Bloomer, B.J.; Clark, D.S.; Hartwig, J.F.
Progress, Challenges, and Opportunities with Artificial Metalloenzymes in Biosynthesis.
Biochem.2023,
62, 221-228.
457. Liu, Z.; Huang, J.; Gu, Y.; Clark, D.S.; Mukhopadhyay, A.; Keasling, J.D.; Hartwig, J.F.
Assembly and Evolution of Artificial Metalloenzymes within E. coli Nissle 1917 for Enantioselective and Site-Selective Functionalization of C-H and C = C Bonds.
J. Am. Chem. Soc.2022,
144, 883-890.
456. Gu, Y.; Bloomer, B.J.; Liu, Z.’ Chen, R.: Clark, D.S.; Hartwig, J.F.
Directed Evolution of Artificial Metalloenzymes in Whole Cells.
Angew. Chem. Int. Ed.2022,
61, e202110519.
455. Su, B.; Hartwig, J.F.
Development of Chiral Ligands for the Transition-Metal-Catalyzed Enantioselective Silylation and Borylation of C−H Bonds.
Angew. Chem. Int. Ed.2022,
61, e202113343.
454. Butcher, T.W.; Amberg, W.M.; Hartwig, J.F.
Transition-Metal-Catalyzed Monofluoroalkylation: Strategies for the Synthesis of Alkyl Fluorides by C-C Bond Formation.
Angew. Chem. Int. Ed.2022,
61, e202112251.
453. Sakamoto, S.; Butcher, T.W.; Yang, J.L.; Hartwig, J.F.
gem-Difluoroallylation of Aryl Halides and Pseudo Halides with Difluoroallylboron Reagents in High Regioselectivity.
Angew. Chem. Int. Ed. 2021,
60, 25746-25752.
452. Huang, J.; Liu, Z.; Bloomer, B.J.; Clark, D.S.; Mukhopadhyay, A.; Keasling, J.D.; Hartwig, J.F.
Unnatural Biosynthesis by an Engineered Microorganism with Heterologously Expressed Natural Enzymes and an Artificial metalloenzyme.
Nat. Chem. 2021,
13, 1186-1191.
451. Day, C.S.; Fawcett, A.; Chatterjee, R.; Hartwig, J.F.
Mechanistic Investigation of the Iron-Catalyzed Azidation of Alkyl C(sp3 )−H Bonds with Zhdankin’s λ3 Azidoiodane.
J. Am. Chem. Soc.2021,
143, 16184-16196.
450. Kalkman, E. D.; Hartwig, J. F.
Direct Observation of Diastereomeric α-C-Bound Enolates during Enantioselective α-Arylations: Synthesis, Characterization, and Reactivity of Arylpalladium Fluorooxindole Complexes.
J. Am. Chem. Soc.2021,
143, 11741-11750.
449. Fuentes, M. A.; Gava, R.; Saper, N. I.; Romero, E.; Caballero, A.; Hartwig, J. F.; Pérez, P. J.
Copper-Catalyzed Dehydrogenative Amidation of Light Alkanes.
Angew. Chem. Int. Ed. 2021,
60, 18467-18471.
448. Chen, L.; Malollari, K.G.; Ullana, A.; Hartwig, J.F.
Ruthenium-Catalyzed, Chemoselective and Regioselective Oxidation of Polyisobutene.
J. Am. Chem. Soc.2021,
143, 4531-4535.
447. Fawcett, A.; Keller, M.J.; Herrera, Z.; Hartwig, J.F.
Site Selective Chlorination of C(sp3)-H Bonds Suitable for Late-Stage Functionalization.
Angew. Chem. Int. Ed.2021,
60, 8276-8283.
445. Ji, P.; Park, J.; Gu, Y.; Clark, D.S.; Hartwig, J.F.
Abiotic reduction of ketones with silanes catalysed by carbonic anhydrase through an enzymatic zinc hydride.
Nat. Chem.2021,
13, 312-318.
444. Chen, L.; Malollari, K.G.; Uliana, A.; Sanchez, D.; Messersmith, P.B.; Hartwig, J.F.
Selective, Catalytic Oxidations of C–H Bonds in Polyethylenes Produce Functional Materials with Enhanced Adhesion.
Chem2021,
7, 137-145.
443. Tlahuext-Aca, A.; Lee, S. Y.; Sakamoto, S.; Hartwig, J.F.
Direct Arylation of Simple Arenes with Aryl Bromides by Synergistic Silver and Palladium Catalysis.
ACS Catal.2021,
11, 1430-1434.
442. Tlahuext-Aca, A.; Hartwig, J.F.
Site-Selective Silver-Catalyzed C–H Bond Deuteration of Five-Membered Aromatic Heterocycles and Pharmaceuticals.
ACS Catal.2021,
11, 1119-1127.
441. Ma, S.; Hill, C.K.; Olen, C.L.; Hartwig, J.F.
Ruthenium-Catalyzed Hydroamination of Unactivated Terminal Alkenes with Stoichiometric Amounts of Alkene and an Ammonia Surrogate by Sequential Oxidation and Reduction.
J. Am. Chem. Soc.2021,
143, 359-368.
440. Xi, Y.; Ma, S.; Hartwig, J.F.
Catalytic asymmetric addition of an amine N–H bond across internal alkenes.
Nature2020,
588, 254-260.
438. Wang, J.Y.; Choi, K.; Zuend, S.J.; Borate, K.; Hartwig, J.F.
Cross-Coupling between Hydrazine and Aryl Halides with Hydroxide Base at Low Loadings of Palladium by Rate-Determining Deprotonation of Bound Hydrazine.
Angew. Chem. Int. Ed.2020,
60, 399-408.
437. Oeschger, R.; Su, B.; Yu, I.; Ehinger, C.; Romero, E.; He, S.; Hartwig, J.F.
Diverse functionalization of strong alkyl C–H bonds by undirected borylation.
Science2020,
368, 736-741.
436. Xi, Y.; Su, B.; Qi, X.; Pedram, S.; Liu, P.; Hartwig, J.F.
Application of Trimethylgermanyl-Substituted Bisphosphine Ligands with Enhanced Dispersion Interactions to Copper-Catalyzed Hydroboration of Disubstituted Alkenes.
J. Am. Chem. Soc.2020,
142, 18213-18222.
435. Richers, C.P.; Roediger, S.; Laserna, V.; Hartwig, J.F.
Effects of Ligands on the Migratory Insertion of Alkenes into Rhodium–Oxygen Bonds.
Chem. Sci.2020,
11, 10449-10456.
434. Butcher, T.W.; Yang, J.L.; Hartwig, J.F.
Copper-Catalyzed Defluorinative Borylation and Silylation of gem-Difluoroallyl Groups.
Org. Lett.2020,
22, 6805-6809.
426. Buchwald, S.L.; Hartwig, J.F.
In Praise of Basic Research as a Vehicle to Practical Applications: Palladium-Catalyzed Coupling to Form Carbon-Nitrogen Bonds.
Isr. J. Chem. 2020,
60, 177-179.
425. Su, B; Bunescu, A.; Qiu, Y.; Zuend, S.J.; Ernst, M.; Hartwig, J.F.
Palladium-Catalyzed Oxidation of β-C(sp3)–H Bonds of Primary Alkylamines through a Rare Four-Membered Palladacycle Intermediate.
J. Am. Chem. Soc.2020,
142, 7912-7919.
424. Saper, N.I.; Ohgi, A.; Small, D.W.; Semba, K.; Nakao, Y.; Hartwig, J.F.
Nickel-catalyzed anti-Markovnikov hydroarylation of unactivated alkenes with unactivated arenes facilitated by non-covalent interactions.
Nat. Chem.2020,
12, 276-283.
423. Larsen, M.A.; Oeschger, R.J.; Hartwig, J.F.
Effect of Ligand Structure on the Electron Density and Activity of Iridium Catalysts for the Borylation of Alkanes.
ACS Catal.2020,
10, 3415-3424.
421. Yoritate, M.; Londregan, A.T.; Lian, Y.; Hartwig, J.F.
Sequential Xanthalation and O‑Trifluoromethylation of Phenols: A Procedure for the Synthesis of Aryl Trifluoromethyl Ethers.
J. Org. Chem.2019,
84, 15767-15776.
420. Karmel, C.; Rubel, C.Z.; Kharitonova, E.V.; Hartwig, J.F.
Iridium‐Catalyzed Silylation of Five‐Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl‐Imidazoline Ligand.
Angew. Chem. Int. Ed.2020,
59, 6074-6081.
418. Oeschger, R.J.; Larsen, M.A.; Bismuto, A.; Hartwig, J.F.
Origin of the Difference in Reactivity between Ir Catalysts for the Borylation of C-H Bonds.
J. Am. Chem. Soc.2019,
141, 16479-16485.
417. He, Z.; Hartwig, J.F.
Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds.
Nat. Comm.2019,
10, 1-4.
416. Kalkman, E.D.; Mormino, M.G.; Hartwig, J.F.
Unusual Electronic Effects of Ancillary Ligands on the Perfluoroalkylation of Aryl Iodides and Bromides Mediated by Copper(I) Pentafluoroethyl Complexes of Substituted Bipyridines.
J. Am. Chem. Soc.2019,
141, 19458-19465.
415. Hartwig, J.F.; Ward, T.R.
New ‘Cats’ in the House: Chemistry Meets Biology in Artificial Metalloenzymes and Repurposed Metalloenzymes.
Acc. Chem. Res.2019,
52, 1145-1145.
411. Hanna, S., Butcher, T.W., Hartwig, J.F.
Contra-thermodynamic Olefin Isomerization by Chain-Walking Hydrofunctionalization and Formal Retro-hydrofunctionalization.
Org. Lett.2019,
21, 7129-7133.
410. Gu, Y., Natoli, S.N., Liu, Z., Clark, D.S., Hartwig, J.F.
Site-Selective Functionalization of (sp3)C-H Bonds Catalyzed by Artificial Metalloenzymes Containing an Iridium-Porphyrin Cofactor.
Angew. Chem. Int. Ed.2019,
58, 13954-13960.
409. He, Z.T., Jiang, X., Hartwig, J.F.
Stereodivergent Construction of Tertiary Fluorides in Vicinal Stereogenic Pairs by Allylic Substitution with Iridium and Copper Catalysts.
J. Am. Chem. Soc.2019,
141, 13066-13073.
408. He, Z.T., Hartwig, J.F.
Palladium-Catalyzed α-Arylation of Carboxylic Acids and Secondary Amides via a Traceless Protecting Strategy.
J. Am. Chem. Soc.2019,
141, 11749-11753.
404. Haydl, A.M., Hartwig, J.F.
Palladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters.
Org. Lett.2019,
21, 1337-1341.
403. He, Z.T., Hartwig, J.F.
Enantioselective α-functionaliations of ketones via allylic substitution of silyl enol ethers.
Nat. Chem.2019,
11, 177.
402. Natoli, S.N., Hartwig, J.F.
Noble-Metal Substitution in Hemoproteins: An Emerging Strategy for Abiological Catalysis.
Acc. Chem. Res.2019,
52, 326-335.
401. Jiang, Q., Peacock, D.M., Hartwig, J.F., Cundari, T.R.
Carbon (sp3)-nitrogen bond-forming reductive elimination from phosphine-ligated alkylpalladium (II) amide complexes: A DFT study.
Tetrahedron2019,
75, 137-143.
400. He, Z., Li, H., Haydl, A. M., Whiteker, G. T., Hartwig, J. F.
Trimethylphosphate as a Methylating Agent for Cross Coupling: A Slow-Release Mechanism for the Methylation of Arylboronic Esters.
J. Am. Chem. Soc.2018,
140, 17197-17202.
399. Su, B.; Lee, T.; Hartwig, J.F.
Iridium-Catalyzed, β-Selective C(sp3)-H Silylation of Aliphatic Amines to Form Silapyrrolidines and 1,2-Amino Alcohols.
J. Am. Chem. Soc.2018,
140, 18032-18038.
398. Peacock, D.M.; Jiang, Q.; Cundari, T.R.; Hartwig, J.F.
Reductive Elimination to Form C(sp3)-N Bonds from Palladium(II) Primary Alkyl Complexes.
Organometallics2018,
37, 3243-3247.
396. Zhang, Q.; Hartwig, J.F.
Synthesis of Heteroaromatic Trifluoromethyl Ethers with Trifluoromethyl Triflate as the Source of the Trifluoromethoxy Group.
Chem. Comm.2018,
54, 10124-10127.
394. Su, B.; Hartwig, J.F.
Iridium‐Catalyzed, Silyl‐Directed, peri‐Borylation of C-H Bonds in Fused Polycyclic Arenes and Heteroarenes.
Angew. Chem. Int. Ed.2018,
57, 10163-10167.
393. Wang, J.Y.; Strom, A.E.; Hartwig, J.F.
Mechanistic Studies of Palladium-Catalyzed Aminocarbonylation of Aryl Chlorides with Carbon Monoxide and Ammonia.
J. Am. Chem. Soc.2018,
140, 7979-7993.
392. Peacock, D.M.; Jiang, Q.; Hanley, P.S.; Cundari, T.R.; Hartwig, J.F.
Reductive Elimination from Phosphine-ligated Alkylpalladium(II) Amido Complexes to Form sp3 Carbon-Nitrogen Bonds.
J. Am. Chem. Soc.2018,
140, 4893-4904.
391. Jiang, X.; Boehm, P.; Hartwig, J.F.
Stereodivergent Allylation of Azaaryl Acetamides and Acetates by Synergistic Iridium and Copper Catalysis.
J. Am. Chem. Soc.2018,
140, 1239-1242.
390. Giri, R.; Brusoe, A.; Troshin, K.; Wang, J.Y.; Font, M.; Hartwig, J.F.
Mechanism of the Ullmann Biaryl Ether Synthesis Catalyzed by Complexes of Anionic Ligands: Evidence for the Reaction of Iodoarenes with Ligated Anionic CuI Intermediates.
J. Am. Chem. Soc.2018,
140, 793-806.
389. Bunescu, A.; Butcher, T.W.; Hartwig, J.F.
Traceless Silylation of β-C(sp3)–H Bonds of Alcohols via Perfluorinated Acetals.
J. Am. Chem. Soc.2018,
140, 1502-1507.
388. Karmel, C.; Li, B.; Hartwig, J.F.
Rhodium-Catalyzed Regioselective Silylation of Alkyl C–H Bonds for the Synthesis of 1,4-Diols.
J. Am. Chem. Soc.2018,
140, 1460-1470.
386. Saper, N.I.; Hartwig, J.F.
Mechanistic Investigations of the Hydrogenolysis of Diaryl Ethers Catalyzed by Nickel Complexes of N-Heterocyclic Carbene Ligands.
J. Am. Chem. Soc.2017,
139, 17667-17676.
384. Hill, C.K.; Hartwig, J.F.
Site-selective oxidation, amination and epimerization reactions of complex polyols enabled by transfer hydrogenation.
Nature Chem.2017,
9, 1213-1221.
380. Troshin, K.; Hartwig, J. F.
Snap deconvolution: An informatics approach to high-throughput discovery of catalytic reactions.
Science2017,
357, 175-181.
379. Jiang, X.; Hartwig, J.F.
Iridium-Catalyzed Enantioselective Allylic Substitution of Aliphatic Esters with Silyl Ketene Acetals as the Ester Enolates.
Angew. Chem. Int. Ed.2017,
56, 8887-8891.
378. Su, B.; Zhou, T.-G.; Xu, P.-L.; Shi, Z.-J.; Hartwig, J. F.
Enantioselective Borylation of Aromatic C−H Bonds with Chiral Dinitrogen Ligands.
Angew. Chem. Int. Ed.2017,
0, 7205-7208.
377. Fier, P.S.; Hartwig, J.F.
Site-Selective C-H Fluorination of Pyridines and Diazines with AgF2.
Org. Synth.2017,
94, 46-53.
373. Wang, Y.; Bartlett, M.J.; Denard, C.A.; Hartwig, J.F.; Zhao, H.
Combining Rh-catalyzed Diazocoupling and Enzymatic Reduction to Efficiently Synthesize Enantioenriched 2-substituted Succinate Derivatives.
ACS. Catal.2017,
7, 2548–2552.
372. Jin, Y.; Chen, M.; Ge, S.; Hartwig, J.F.
Palladium-Catalyzed, Enantioselective α‑Arylation of α‑Fluorooxindoles.
Org. Lett.2017,
19, 1390–1393.
371. Litman, Z.C.; Sharma, A.; Hartwig, J.F.
Oxidation of Hindered Allylic C-h Bonds with Applications to the Functionalization of Complex Molecules.
ACS Catal.2017,
7, 1998-2001.
369. Dydio, P.; Key, H.M.; Hayashi, H.; Clark, D.S.; Hartwig, J.F.
Chemoselective, Enzymatic C-H Bond Amination Catalyzed by a Cytochrome P450 Containing an Ir(Me)-PIX Cofactor.
J. Am. Chem. Soc.2017,
139, 1750–1753.
368. Jiang, X.; Beiger, J. J.; Hartwig, J. F.
Stereodivergent Allylic Substitutions with Aryl Acetic Acid Esters by Synergistic Iridium and Lewis Base Catalysis.
J. Am. Chem. Soc.2017,
139, 87–90.
367. Su, B.; Zhou, T.; Li, X.; Shao, X.; Xu, P.; Wu, W.; Hartwig, J.F.; Shi, Z.
A Chiral Nitrogen Ligand for Enantioselective, Iridium-Catalyzed Silylation of Aromatic C-H Bonds.
Angew. Chem. Int. Ed. 2017,
56, 1092–1096.
365. Lee, S.Y.; Hartwig, J.F.
Palladium-Catalyzed, Site-Selective Direct Allylation of Aryl C-H Bonds by Silver-Mediated C-H Activation: A Synthetic and Mechanistic Investigation.
J. Am. Chem. Soc.2016,
138, 15278–15284.
364. Zhang, J.; Shrestha, R.; Hartwig, J.F.; Zhao, P.
A Decarboxylative Approach for Regioselective Hydroarylation of Alkynes.
Nature Chem.2016,
8, 1144–1151.
346. Wang, D.Y.; Choliy, Y.; Haibach, M.C.; Hartwig, J.F.; Krogh-Jespersen, K.; Goldman, A.S
Assessment of the Electronic Factors Determining the Thermodynamics of "Oxidative Addition" of C–H and N–H Bonds to Ir(I) Complexes.
J. Am. Chem. Soc.2016,
138, 149-163.
342. Madrahimov, S.T.; Li, Q.; Sharma, A.; Hartwig, J.F.
Origins of Regioselectivity in Iridium Catalyzed Allylic Substitution.
J. Am. Chem. Soc.2015,
137, 14968-14981.
341. Chen, M.; Hartwig, J.F.
Iridium-Catalyzed Enantioselective Allylic Substitution of Enol Silanes from Vinylogous Esters and Amides.
J. Am. Chem. Soc.2015,
137, 13972-13979.
340. Schramm, Y.; Takeuchi, M.; Semba, K.; Nakao, Y.; Hartwig, J.F.
Anti-Markovnikov Hydroheteroarylation of Unactivated Alkenes with Indoles, Pyrroles, Benzofurans, and Furans Catalyzed by a Nickel–N-Heterocyclic Carbene System.
J. Am. Chem. Soc.2015,
137, 12215–12218.
339. Larsen, M.A.; Wilson, C.V.; Hartwig, J.F.
Iridium-Catalyzed Borylation of Primary Benzylic C–H Bonds without a Directing Group: Scope, Mechanism, and Origins of Selectivity.
J. Am. Chem. Soc.2015,
137, 8633-8643.
336. Key, H.M.; Clark, D.S.; Hartwig, J.F.
Generation, Characterization, and Tunable Reactivity of Organometallic Fragments Bound to a Protein Ligand.
J. Am. Chem. Soc.2015,
137, 8261-8268.
335. Lee, T.; Wilson, T.W.; Berg, R.; Ryberg, P.; Hartwig, J.F.
Rhodium-Catalyzed Enantioselective Silylation of Arene C-H bonds: Desymmetrization of Diarylmethanols.
J. Am. Chem. Soc.2015,
137, 6742-6745.
334. Denard, C.A.; Bartlett, M.J.; Wang, J.; Lu, L.; Hartwig, J.F.; Zhao, H.
Development of a one-pot tandem reaction combining ruthenium-catalyzed alkene metathesis and enantioselective enzymatic oxidation to produce aryl epoxides.
ACS Catal.2015,
5, 3817-3822.
331. Sharma, A.; Hartwig, J.H.
Metal-Catalyzed Azidation of Tertiary C–H Bonds Suitable for Late-Stage Functionalization.
Nature2015,
517, 600-604.
330. Tran, B. L.; Driess, M.; Hartwig, J. F.
Copper-Catalyzed Oxidative Dehydrogenative Carboxylation of Unactivated Alkanes to Allylic Esters via Alkenes.
J. Am. Chem. Soc.2014,
136, 17292-17301.
329. Ge, S.; Arlow, S.I.; Mormino, M.G.; Hartwig, J.F.
Pd-Catalyzed α‑Arylation of Trimethylsilyl Enolates of α,α-Difluoroacetamides.
J. Am. Chem. Soc.2014,
136, 14401-14404.
328. Chen, W.; Chen, M.; Hartwig, J.F.
Diastereo- and Enantioselective Iridium-Catalyzed Allylation of Cyclic Ketone Enolates: Synergetic Effect of Ligands and Barium Enolates.
J. Am. Chem. Soc.2014,
136, 15825-15828.
327. Bair, J.S.; Schramm, Y.; Sergeev, A.G.; Clot, E.; Eisenstein, O.; Hartwig, J.F.
Linear-Selective Hydroarylation of Unactivated Terminal and Internal Olefins with Trifluoromethyl-Substituted Arenes.
J. Am. Chem. Soc.2014,
136, 13098-13101.
326. Chen, M.; Hartwig, J.F.
Iridium-Catalyzed Regio- and Enantioselective Allylic Substitution of Silyl Dienolates Derived from Dioxinones.
Angew. Chem. Int. Ed.2014,
53, 1-6.
323. Fier, P.S.; Hartwig, J.F.
Synthesis and Late-Stage Functionalization of Complex Molecules through C−H Fluorination and Nucleophilic Aromatic Substitution.
J. Am. Chem. Soc.2014,
136, 10139-10147.
322. Green, R.A.; Hartwig, J.F.
Palladium-Catalyzed Amination of Aryl Chlorides and Bromides with Ammonium Salts.
Org. Lett.2014,
16, 4388−4391.
321. Li, B.; Driess, M.; Hartwig, J.F.
Iridium-Catalyzed Regioselective Silylation of Secondary Alkyl C−H Bonds for the Synthesis of 1,3-Diols.
J. Am. Chem. Soc.2014,
136, 6586-6589.
320. Li, Q.; Driess, M.; Hartwig, J.F.
Iridium-Catalyzed Regioselective Silylation of Aromatic and Benzylic C-H Bonds Directed by a Secondary Amine.
Angew. Chem. Int. Ed.2014,
53, 1-5.
319. Li, Q.; Liskey, C.W.; Hartwig, J.F.
Regioselective Borylation of the C–H Bonds in Alkylamines and Alkyl Ethers. Observation and Origin of High Reactivity of Primary C–H Bonds Beta to Nitrogen and Oxygen.
J. Am. Chem. Soc.2014,
136, 8755–8765.
318. Chen, M.; Hartwig, J.F.
Iridium-Catalyzed Enantioselective Allylic Substitution of Unstabilized Enolates Derived from α,β-Unsaturated Ketones.
Angew. Chem. Int. Ed.2014,
53, 1-6.
317. Mormino, M.G.; Fier, P.S.; Hartwig, J.F.
Copper-Mediated Perfluoroalkylation of Heteroaryl Bromides with (phen)CuRF.
Org. Lett.2014,
16, 1744-1747.
316. Cho, S.H.; Hartwig, J.F.
Iridium-catalyzed diborylation of benzylic C–H bonds directed by a hydrosilyl group: synthesis of 1,1-benzyldiboronate esters.
Chem. Sci.2014,
5, 694-698.
315. Larsen, M.A.; Hartwig, J.F.
Iridium-Catalyzed C−H Borylation of Heteroarenes: Scope, Regioselectivity, Application to Late-Stage Functionalization, and Mechanism.
J. Am. Chem. Soc.2014,
136, 4287-4299.
314. Ge, S.; Chaładaj, W.; Hartwig, J.F.
Pd-Catalyzed α‐Arylation of α,α-Difluoroketones with Aryl Bromides and Chlorides. A Route to Difluoromethylarenes.
J. Am. Chem. Soc.2014,
136, 4149-4152.
313. Cheng, C.; Hartwig, J.F.
Rhodium-Catalyzed Intermolecular C–H Silylation of Arenes with High Steric Regiocontrol.
Science.2014,
343, 853-857.
312. Sevov, C.S; Zhou, J. (Steve); Hartwig, J.H.
Iridium-Catalyzed, Intermolecular Hydroamination of Unactivated Alkenes with Indoles.
J. Am. Chem. Soc.2014,
136, 3200-3207.
311. Tran, B.L.; Li, B.; Driess, M.; Hartwig, J.F.
Copper-Catalyzed Intermolecular Amidation and Imidation of Unactivated Alkanes.
J. Am. Chem. Soc.2014,
136, 2555-2563.
310. Ge. S.; Green, R.A.; Hartwig, J.F.
Controlling First-Row Catalysts: Amination of Aryl and Heteroaryl Chlorides and Bromides with Primary Aliphatic Amines Catalyzed by a BINAP-Ligated Single-Component Ni(0) Complex.
J. Am. Chem. Soc.2014,
136, 1617-1627.
309. Chen, W.; Hartwig, J.F.
Cation Control of Diastereoselectivity in Iridium-Catalyzed Allylic Substitutions. Formation of Enantioenriched Tertiary Alcohols and Thioethers by Allylation of 5H-Oxazol-4-ones and 5H-Thiazol-4-ones.
J. Am. Chem. Soc.2014,
136, 377-382.
308. Denard, C.A.; Huang, H.; Bartlett, M.J.; Lu, L.; Tan, Y.; Zhao, H.; Hartwig, J.F.
Cooperative Tandem Catalysis by an Organometallic Complex and a Metalloenzyme.
Angew. Chem. Int. Ed.2014,
53, 465-469.
307. Hama, T.; Ge, S.; Hartwig, J.F.
Palladium-Catalyzed α-Arylation of Zinc Enolates of Esters: Reaction Conditions and Substrate Scope.
J. Org. Chem.2013,
78, 8250-8266.
306. Denard, C.A.; Hartwig, J.F.; Zhao, H.
Multistep One-Pot Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis.
ACS Catal.2013,
3, 2856-2864.
305. Fier, P.S.; Hartwig, J.F.
Selective C-H Fluorination of Pyridines and Diazines Inspired by a Classic Amination Reaction.
Science2013,
342, 956-960.
304. Sharma, A.; Hartwig, J.F.
Enantioselective Functionalization of Allylic C–H Bonds Following a Strategy of Functionalization and Diversification.
J. Am. Chem. Soc.2013,
135, 17983-17989.
303. Gallego, D.; Brück, A.; Irran, E.; Meier, F.; Kaupp, M.; Driess, M.; Hartwig, J.F.
From Bis(silylene) and Bis(germylene) Pincer-Type Nickel(II) Complexes to Isolable Intermediates of the Nickel-Catalyzed Sonogashira Cross-Coupling Reaction.
J. Am. Chem. Soc.2013,
135, 15617-15626.
301. Strom, A.E.; Hartwig, J.H.
One-Pot Anti-Markovnikov Hydroamination of Unactivated Alkenes by Hydrozirconation and Amination.
J. Org. Chem.2013,
78, 8909-8914.
294. Chen, W.; Hartwig, J.F.
Control of Diastereoselectivity for Iridium-Catalyzed Allylation of a Prochiral Nucleophile with a Phosphate Counterion.
J. Am. Chem. Soc.2013,
135, 2068−2071.
288. Ge, S.; Hartwig, J.F.
Highly Reactive, Single-Component Nickel Catalyst Precursor for Suzuki-Miyuara Cross-Coupling of Heteroaryl Boronic Acids with Heteroaryl Halides.
Angew. Chem. Int. Ed.2012,
51, 12837–12841.
287. Bruck, A.; Gallego, D.; Wang, W. Y.; Irran, E.; Driess, M.; Hartwig, J. F.
Pushing the σ-Donor Strength in Iridium Pincer Complexes: Bis(silylene) and Bis(germylene) Ligands Are Stronger Donors than Bis(phosphorus(III)) Ligands.
Angew. Chem. Int. Ed.2012,
51, 11478–11482.
286. Sergeev, A.G.; Webb, J.D.; Hartwig, J.F.
A Heterogeneous Nickel Catalyst for the Hydrogenolysis of Aryl Ethers without Arene Hydrogenation.
J. Am. Chem. Soc.2012,
134, 20226–20229.
285. Chen, C.; Weng, Z.; Hartwig, J.F.
Synthesis of Copper(I) Thiolate Complexes in the Thioetherification of Aryl Halides.
Organometallics2012,
31, 8031–8036.
283. Litvinas, N.D.; Fier, P.S.; Hartwig, J.F.
A General Strategy for the Perfluoroalkylation of Arenes and Arylbromides by Using Arylboronate Esters and [(phen)CuRF.
Angew. Chem. Int. Ed.2012,
51, 536-539.
282. Hanley, P.S.; Marquard, S.L.; Cundari, T.R.; Hartwig, J.F.
Reductive Elimination of Alkylamines from Low-Valent, Alkylpalladium(II) Amido Complexes.
J. Am. Chem. Soc.2012,
134, 15281–15284.
281. Robbins, D.W.; Hartwig, J.F.
A C-H Borylation Approach to Suzuki-Miyaura Coupling of Typically Unstable 2-Heteroaryl and Polyfluorophenyl Boronates.
Org. Lett.2012,
14, 4266–4269.
274. Simmons, E.M.; Hartwig, J.F.
Catalytic functionalization of unactivated primary C–H bonds directed by an alcohol.
Nature2012,
483, 70–73.
273. Tan, Y.; Barrios-Landeros, F; Hartwig, J.F.
Mechanistic Studies on Direct Arylation of Pyridine N-Oxide: Evidence for Cooperative Catalysis between Two Distinct Palladium Centers.
J. Am. Chem. Soc. 2012,
134, 3683–3686.
266. Hanley, P.S.; Hartwig, J.F.
Intermolecular Migratory Insertion of Unactivated Olefins into Palladium–Nitrogen Bonds. Steric and Electronic Effects on the Rate of Migratory Insertion.
J. Am. Chem. Soc. 2011,
133, 15661-15673.
265. Ge, S.; Hartwig, J.F.
Nickel-catalyzed Asymmetric α-Arylation and Heteroarylation of Ketones with Chloroarenes: Effect of Halide on Selectivity, Oxidation State and Room Temperature Reactions.
J. Am. Chem. Soc2011,
133, 16330-16333.
264. Robbins, D.W.; Hartwig, J.F.
A Simple, Multi-Dimensional Approach to High-Throughput Discovery of Catalytic Reactions.
Science2011,
333, 1423-1427.
263. Zhijian Liu, Z.; Yamamichi, H.; Madrahimov, S.T.; Hartwig, J.F.
Rhodium Phosphine-π-Arene Intermediates in the Hydroamination of Alkenes.
J. Am. Chem. Soc2011,
133, 2772-2782.
262. Tan, Y.; Hartwig, J. F.
Assessment of the Intermediacy of Arylpalladium Carboxylate Complexes in the Direct Arylation of Benzene: Evidence for C-H Bond Cleavage by ‘Ligandless’ Species.
J. Am. Chem. Soc2011,
133, 3308-3311.
261. Carrow, B. P.; Hartwig, J. F.
Distinguishing Between Pathways for Transmetalation in Suzuki-Miyaura Reactions.
J. Am. Chem. Soc2011,
133, 2116-2119.
260. Huang, D.S.; DeLuca, R. J.; Hartwig, J.F.
α-Arylation of Esters Catalyzed by the Pd(I) Dimer [P(t-Bu)3]Pd(m-Br)]2.
Org. Synth.2011,
88, 4-13.
259. Liao, X.; Stanley, L.M.; Hartwig, J.F.
Enantioselective Total Syntheses of (−)-Taiwaniaquinone H and (−)-Taiwaniaquinol B by Iridium-Catalyzed Borylation and Palladium-Catalyzed Asymmetric α-Arylation.
J. Am. Chem. Soc. 2011,
133, 2088-2091.
255. Julian, J.D.; Hartwig, J.F.
Intramolecular Hydroamination of Unbiased and Functionalized Primary Aminoalkenes Catalyzed by a Rhodium Aminophosphine Complex.
J. Am. Chem. Soc. 2010,
132, 13813-13822.
254. Giri, R.: Hartwig, J.F.
Cu(I) Amido Complexes in the Ullmann Reaction. Reactions of Cu(I)-Amido Complexes with Iodoarenes with and without Autocatalysis by CuI.
J. Am. Chem. Soc. 2010,
132, 15860-15863.
248. Huang, Z.; Zhou, J. Hartwig, J.F.
N-H Activation of Hydrazines by Iridium(I). Double N-H Activation to Form Iridium Aminonitrene Complexes.
J. Am. Chem. Soc. 2010,
132, 11458-11460.
247. Stanley, L. M.; Bai, C.; Ueda, M.; Hartwig, J. F.
Iridium-Catalyzed Kinetic Asymmetric Transformations of Racemic Allylic Benzoates.
J. Am. Chem. Soc. 2010,
132, 8918-8920.
246. Fernandez-Rodriguez, M.A.; Hartwig, J.F.
One-Pot Synthesis of Unsymmetrical Diaryl Thioethers by Palladium-Catalyzed Coupling of Two Aryl Bromides and a Thiol Surrogate.
Chem. Eur. J.2010,
16, 2355-2359.
245. Hanley, P.S.; Markovic, D.; Hartwig, J.F.
Intermolecular Insertion of Ethylene and Octene into a Palladium-Amide Bond. Spectroscopic Evidence for an Ethylene Amido Intermediate.
J. Am. Chem. Soc.2010,
132, 6302-6303.
244. Robbins, D.W.; Boebel, T. A.; Hartwig, J.F.
Iridium-Catalyzed, Silyl-Directed Borylation of Nitrogen-Containing Heterocycles.
J. Am. Chem. Soc. 2010,
132, 4068-4069.
241. Sawyer, K.R., Cahoon, J.F., Shanoski, J.E., Glascoe, E.A., Kling, M.F., Schlegel, J.P., Zoerb, M.C., Hapke, M., Hartwig, J.F., Webster, C.E., Harris, C.B.
Time-resolved IR Studies on the Mechanism for the Functionalization of Primary C−H Bonds by Photoactivated Cp*W(CO)3(Bpin).
J. Am. Chem. Soc.2010,
132, 1848-1859.
240. Wei, C.S.; Jiménez-Hoyos, C.A.; Videa, M.F.; Hartwig, J.F.; Hall, M.B.
Origins of the Selectivity for Borylation of Primary over Secondary C–H Bonds Catalyzed by Cp*-Rhodium Complexes.
J. Am. Chem. Soc.2010,
132, 3078-3091.
236. Carrow, B.P.; Hartwig, J.F.
Ligandless, Anionic, Arylpalladium Halide Intermediates in the Heck Reaction.
J. Am. Chem. Soc.2009,
132, 79-81.
235. Ueda, M.; Hartwig, J.F.
Iridium-Catalyzed Regio- and Enantioselective Allylic Substitution with Aromatic and Aliphatic Sulfinates.
Org. Lett.2009,
12, 92-94.
234. Tye, J.W.; Hartwig, J.F.
Computational Studies on the Relative Rates for Migratory Insertions of Alkenes into Square-Planar Rhodium–Methyl, –Amide, and –Hydroxide Complexes.
J. Am. Chem. Soc. 2009,
131, 14703.
233. Liskey, C.W., Wei, C.S., Pahls, D.R., Hartwig J.F.
Pronounced Effects of Substituents on the Iridium-Catalyzed Borylation of Aryl C–H Bonds.
Chem. Commun.2009,
0, 5603-5605.
230. Vo, G.D.; Hartwig, J.F.
Palladium-Catalyzed Coupling of Ammonia with Aryl Chlorides, Bromides, Iodides, and Sulfonates: A General Method for the Preparation of Primary Arylamines.
J. Am. Chem. Soc.2009,
131, 11049-11061.
229. Weix, D.J.; Markovic, D.; Ueda, M.; Hartwig, J.F.
Direct, Intermolecular, Enantioselective, Iridium-Catalyzed Allylation of Carbamates to Form Carbamate-Protected, Branched Allylic Amines..
Org. Lett.2009,
11, 2944–2947.
228. Stanley, L. M.; Hartwig, J. F.
Regio- and Enantioselective N-Allylations of Imidazole, Benzimidazole, and Purine Heterocycles Catalyzed by Single-Component Metallacyclic Iridium Complexes.
J. Am. Chem. Soc.2009,
131, 8971-8983.
227. Alvaro, E.; Hartwig, J.F.
Resting State and Elementary Steps of the Coupling of Aryl Halides with Thiols Catalyzed by Alkylbisphosphine Complexes of Palladium.
J. Am. Chem. Soc.2009,
131, 7858–7868.
226. Barrios-Landeros, F.; Carrow, B.P.; Hartwig, J.F
Effect of Ligand Steric Properties and Halide Identity on the Mechanism for Oxidative Addition of Haloarenes to Trialkylphosphine Pd(0) Complexes.
J. Am. Chem. Soc.2009,
131, 8141-8154.
225. Madrahimov, S.T.; Markovic, D.; Hartwig, J.F.
The Allyl Intermediate in Regioselective and Enantioselective Iridium-Catalyzed Asymmetric Allylic Substitution Reaction.
J. Am. Chem. Soc.2009,
131, 7228-7229.
224. Fernandez-Rodríguez, M.A.; Hartwig, J.F.
A General, Efficient, and Functional-Group-Tolerant Catalyst System for the Palladium-Catalyzed Thioetherification of Aryl Bromides and Iodides.
J. Org. Chem.2009,
74, 1663-1672.
222. Hartwig, J.F.
Evolution of a Fourth Generation Catalyst for the Amination and Thioetherification of Aryl Halides.
Acc. Chem. Res.2008,
41, 1534-1544.
221. Hartwig, J.F.
Carbon–Heteroatom Bond Formation Catalysed by Organometallic Complexes.
Nature2008,
455, 314-322.
220. Boebel, T.A.; Hartwig, J.F.
Conversion of 1,3-Disubstituted Arenes to Chiral α,α-Diaryl Methylammonium Chlorides Using Arene Borylation.
Tetrahedron2008,
64, 6824-6830.
219. Boebel, T.A.; Hartwig, J.F.
Iridium-Catalyzed Preparation of Silylboranes by Silane Borylation and Their Use in the Catalytic Borylation of Arenes.
Organometallics2008,
27, 6013-6019.
215. Zhou, J. and J.F. Hartwig
Intermolecular, Catalytic Asymmetric Hydroamination of Bicyclic Alkenes and Dienes in High Yield and Enantioselectivity..
J. Am. Chem. Soc.2008,
130, 12220-12221.
214. Zhao, P. and J.F. Hartwig
Insertions of Ketones and Nitriles into Organorhodium(I) Complexes and b-Hydrocarbyl Eliminations from Rhodium(I) Alkoxo and Iminyl Complexes..
Organometallics2008,
27, 4749-4757.
213. Shen, Q. and J.F. Hartwig
[(CyPF-tBu)PdCl2]: An Air-Stable, One-Component, Highly Efficient Catalyst for Amination of Heteroaryl and Aryl Halides..
Org. Lett.2008,
18, 4109-4112.
212. Tye, J.W., Weng, Z., Johns, A. M., Incarvito, C. D., and J. F. Hartwig
Copper Complexes of Anionic Nitrogen Ligands in the Amidation and Imidation of Aryl Halides..
J. Am. Chem. Soc.2008,
130, 9971-9983.
211. Liao, X., Weng, Z., and J. F. Hartwig
Enantioselective-Arylation of Ketones with Aryl Triflates Catalyzed by Difluorphos Complexes of Palladium and Nickel.
J. Am. Chem. Soc.2008,
130, 195-200.
210. Liu, Z., and J.F. Hartwig
Mild, Rhodium-Catalyzed Intramolecular Hydroamination of Unactivated Terminal and Internal Olefins with Primary and Secondary Amines..
J. Am. Chem. Soc.2008,
130, 1570-1571.
208. Vo, G.D., and J.F. Hartwig
Palladium-Catalyzed α-Arylation of Aldehydes with Bromo- and Chloroarenes Catalyzed by [Pd(allyl)Cl]2 and DPPF or Q-phos..
Angew. Chem. Int. Ed.2008,
47, 2127-2130.
207. Shen, Q., Ogata, T., and J.F. Hartwig
Highly Reactive, General and Long-Lived Catalysts for Palladium-Catalyzed Amination of Heteroaryl and Aryl Chlorides, Bromides and Iodides: Scope and Structure-Activity Relationships..
J. Am. Chem. Soc.2008,
130, 6586-6596.
206. Barrios-Landeros, F., Carrow, B.P., and J.F. Hartwig
Autocatalytic Oxidative Addition of PhBr to Pd(PtBu3)2 via Pd(PtBu3)2(H)(Br)..
J. Am. Chem. Soc.2008,
130, 5842-5843.
205. Hagedorn, K.V., Varnavski, O., Hartwig, J.F; Goodson III, T.
Exciton Trapping in an Organic Dendrimer Possessing No Energy Gradient..
J. Phys. Chem. C.2008,
112, 2235-2238.
203. Hama, T., and J.F. Hartwig
a-Arylation of Esters Catalyzed by the Pd(I) Dimer {[P(t-Bu)3]PdBr}2..
Org. Lett.2008,
10, 1545-1548.
202. Boebel, T.A. and J.F. Hartwig
Silyl-Directed, Iridium-Catalyzed ortho-Borylation of Arenes. A One-Pot ortho-Borylation of Phenols, Arylamines, and Alkylarenes..
J. Am. Chem. Soc.2008,
130, 7534-7535.
200. Murphy, J.M., Liao, X., and J. F. Hartwig
Meta Halogenation of 1,3-Disubstituted Arenes via Iridium-Catalyzed Arene Borylation..
J. Am. Chem. Soc.2007,
129, 15434-15435.
199. Stambuli, J.P., Weng, Z., Incarvito, C.D., and J. F. Hartwig
Reductive Elimination of Ether from T-Shaped, Monomeric Arylpalladium Alkoxides..
Angew. Chem. Int. Ed.2007,
46, 7674-7677.
198. Johns, A.M., Liu, Z., and J. F. Hartwig
Primary tert- and sec-Allylamines via Palladium-Catalyzed Hydroamination and Allylic Substitution with Hydrazine and Hydroxylamine Derivatives..
Angew. Chem. Int. Ed.2007,
46, 7259-7261.
197. Markovic, D. and J. F. Hartwig
Resting State and Kinetic Studies on the Asymmetric Allylic Substitutions Catalyzed by Iridium-Phosphoramidite Complexes..
J. Am. Chem. Soc.2007,
129, 11680-11681.
196. Pouy, M. J., Leitner, A., Weix, D. J., Ueno, S. and J. F. Hartwig
Enantioselective Iridium-Catalyzed Allylic Amination of Ammonia and Convenient Ammonia Surrogates.
Org. Lett.2007,
9, 3949-3952.
195. Shen, Q. and J. F. Hartwig
Lewis Acid Acceleration of C-N Bond-Forming Reductive Elimination from Heteroarylpalladium Complexes and Catalytic Amidation of Heteroaryl Bromides.
J. Am. Chem. Soc.2007,
129, 7734-7735.
193. Yamashita, Y., Gopalarathnam, A., and J. F. Hartwig
Iridium-Catalyzed, Asymmetric Amination of Allylic Alcohols Activated by Lewis Acids.
J. Am. Chem. Soc.2007,
129, 7508-7509.
192. Herzon, S. B., and J. F. Hartwig
Direct, Catalytic Hydroaminoalkylation of Unactivated Olefins with N-Alkyl Arylamines.
J. Am. Chem. Soc.2007,
129, 6690-6691.
191. Hartwig, J. F.
Electronic Effects on Reductive Elimination To Form Carbon-Carbon and Carbon-Heteroatom Bonds from Palladium(II) Complexes.
Inorg. Chem2007,
46, 1936-1947.
190. Tzschucke, C. C., Murphy, J. M., and J. F. Hartwig
Arenes to Anilines and Aryl Ethers by Sequential Iridium-Catalyzed Borylation and Copper-Catalyzed Coupling.
Org. Lett.2007,
9, 761-764.
189. Murphy, J. M., Tzschucke, C. C., and J. F. Hartwig
One-Pot Synthesis of Arylboronic Acids and Aryl Trifluoroborates by Ir-Catalyzed Borylation of Arenes.
Org. Lett.2007,
9, 757-760.
188. Zhao, P., Incarvito, C. D. and J. F. Hartwig
Directly Observed Transmetalation from Boron to Rhodium. b-Aryl Elimination from Rh(I) Arylboronates and Diarylborinates.
J. Am. Chem. Soc2007,
129, 1876-1877.
187. Shekhar, S., and J. F. Hartwig
Effects of Bases and Halides on the Amination of Chloroarenes Catalyzed by Pd[P(tBu3)]2.
Organometallics2007,
26, 340-351.
184. Johns, A. M, Tye, J. W., and J. F. Hartwig
Relative Rates for the Aminations of h3-Allyl and h3-Benzyl Complexes of Palladium.
J. Am. Chem. Soc.2006,
128, 16010-16011.
183. Takemiya, A., and J. F. Hartwig
Palladium-Catalyzed Synthesis of Aryl Ketones by Coupling of Aryl Bromides with an Acyl Anion Equivalent.
J. Am. Chem. Soc.2006,
128, 14800-14801.
182. Fernandez-Rodríguez, M. A., Shen, Q., and J. F. Hartwig
Highly Efficient and Functional-Group-Tolerant Catalysts for the Palladium-Catalyzed Coupling of Aryl Chlorides with Thiols.
Chem. Eur. J.2006,
12, 7782-7796.
181. Murphy, J. M., Lawrence, J. D., Kawamura, K., Incarvito, C., and J. F. Hartwig
Ruthenium-Catalyzed Regiospecific Borylation of Methyl C-H Bonds.
J. Am. Chem. Soc.2006,
128, 13684-13685.
180. Rosenfeld, D. C., Shekhar, S., Takemiya, A., Utsunomiya, M., and J. F. Hartwig
Hydroamination and Hydroalkoxylation Catalyzed by Triflic Acid. Parallels to Reactions Initiated with Metal Triflates.
Org. Lett.2006,
8, 4179-4182.
179. Shekhar, S., Trantow, B., Leitner, A., and J. F. Hartwig
Sequential Catalytic Isomerization and Allylic Substitution. Conversion of Racemic Branched Allylic Carbonates to Enantioenriched Allylic Substitution Products.
J. Am. Chem. Soc.2006,
128, 11770-11771.
178. Su, W.; Raders, S.; Verkade, J.G.; Liao, X; Hartwig, J.F.
Palladium-Catalyzed alpha-Arylation of Trimethylsilyl Enol Ethers with Aryl Bromides and Chlorides. A Synergistic Effect of Two Metal Fluorides as Additives.
Angew. Chem. Int. Ed.2006,
45, 5852-5855.
176. Zhao, P., Incarvito, C.D., and J. F. Hartwig
Carbon-Oxygen Bond Formation between a Terminal Alkoxo Ligand and a Coordinated Olefin. Evidence for Olefin Insertion into a Rhodium-Alkoxide.
J. Am. Chem. Soc.2006,
128, 9642-9643.
175. Fujita, K.I., Yamashita, M, Puschmann, F., Alvarez-Falcon, M.M., Incarvito, C.D., and J. F. Hartwig
Organometallic Chemistry from Amidate Complexes. Reductive elimination of N-Aryl Amidates from Palladium(II).
J. Am. Chem. Soc.2006,
128, 9044-9045.
174. J.F. Hartwig
Discovery and Understanding of Transition Metal-Catalyzed Aromatic Substitution Reactions.
Synlett2006,
0, 1283-1294.
173. Sakai, N., Ridder, A., J. F. Hartwig
Tropene Derivatives by Sequential Intermolecular and Transannular, Intramolecular Palladium-Catalyzed Hydroamination of Cycloheptatriene.
J. Am. Chem. Soc.2006,
128, 8134-8135.
172. Johns, A.M., Sakai, N., Ridder, A., and J. F. Hartwig
Direct Measurement of the Thermodynamics of Vinylarene Hydroamination.
J. Am. Chem. Soc.2006,
128, 9306-9307.
171. Takemiya, A., and J.F. Hartwig
Rhodium-Catalyzed Intramolecular, Anti-Markovnikov Hydroamination. Synthesis of 3-Arylpiperidines.
J. Am. Chem. Soc.2006,
128, 6042-6043.
170. Hama, T., Culkin, D. A., and J. F. Hartwig
Palladium-Catalyzed Intermolecular a-Arylation of Zinc Amide Enolates under Mild Conditions.
J. Am. Chem. Soc.2006,
128, 4976-4985.
169. Johns, A. M., Utsunomiya, M., Incarvito, C. D., and J. F. Hartwig
A Highly Active Palladium Catalyst for Intermolecular Hydroamination. Factors that Control Reactivity and Additions of Functionalized Anilines to Dienes and Vinylarenes.
J. Am. Chem. Soc.2006,
128, 1828-1839.
168. Fernández-Rodríguez, M. A., Shen, Q., and J. F. Hartwig
A General and Long-Lived Catalyst for the Palladium-Catalyzed Coupling of Aryl Halides with Thiols.
J. Am. Chem. Soc.2006,
128, 2180-2181.
167. Shekhar, S., Ryberg, P., and J. F. Hartwig
Oxidative Addition of Phenyl Bromide to Pd(BINAP) vs Pd(BINAP)(amine). Evidence for Addition to Pd(BINAP).
Org. Lett.2006,
8, 851-854.
166. Shekhar, S., Ryberg, P., Hartwig, J. F., Mathew, J. S., Blackmond, D. G., Strieter, E. R., and S. L. Buchwald
Reevaluation of the Mechanism of the Amination of Aryl Halides Catalyzed by BINAP-Ligated Palladium Complexes.
J. Am. Chem. Soc.2006,
128, 3584-3591.
164. Barrios-Landeros, F. and J. F. Hartwig
Distinct Mechanisms for the Oxidative Addition of Chloro-, Bromo-, and Iodoarenes to a Bisphosphine Palladium(0) Complex with Hindered Ligands.
J. Am. Chem. Soc.2005,
127, 6944-6945.
163. Bae, C., Hartwig, J. F., Boaen Harris, N. K., Long, R. O., Anderson, K. S., and M. A. Hillmyer
Catalytic Hydroxylation of Polypropylenes.
J. Am. Chem. Soc.2005,
127, 767-776.
162. Boller, T. M., Murphy, J. M., Hapke, M., Ishiyama, T., Miyaura, N., and J. F. Hartwig
Mechanism of the Mild Functionalization of Arenes by Diboron Reagents Catalyzed by Iridium Complexes. Intermediacy and Chemistry of Bipyridine-Ligated Iridium Trisboryl Complexes.
J. Am. Chem. Soc.2005,
127, 14263-14278.
159. Hartwig, J. F., Cook, K. S., Hapke, M., Incarvito, C. D., Fan, Y., Webster, C. E., and M. B. Hall
Rhodium Boryl Complexes in the Catalytic, Terminal Functionalization of Alkanes.
J. Am. Chem. Soc.2005,
127, 2538-2552.
158. Lee, D.-Y. and J. F. Hartwig
Zinc Trimethylsilylamide as a Mild Ammonia Equivalent and Base for the Amination of Aryl Halides and Triflates.
Org. Lett.2005,
7, 1169-1172.
157. Leitner, A., Shekhar, S., Pouy, M. J., and J. F. Hartwig
A Simple Iridium Catalyst with a Single Resolved Stereocenter for Enantioselective Allylic Amination. Catalyst Selection from Mechanistic Analysis.
J. Am. Chem. Soc.2005,
127, 15506-15514.
156. Leitner, A., Shu, C., and J. F. Hartwig
Effects of Catalyst Activation and Ligand Steric Properties on the Enantioselective Allylation of Amines and Phenoxides.
Org. Lett.2005,
7, 1093-1096.
155. Limmert, M. E., Roy, A. H., and J. F. Hartwig
Kumada Coupling of Aryl and Vinyl Tosylates under Mild Conditions.
J. Org. Chem.2005,
127, 9364-9370.
154. Shen, Q., Shekhar, S., Stambuli, J. P., and J. F. Hartwig
Highly Reactive, General, and Long-Lived Catalysts for Coupling Heteroaryl and Aryl Chlorides with Primary Nitrogen Nucleophiles..
Angew. Chem. Int. Ed.2005,
44, 1371-1375.
153. Takaya, J. and J. F. Hartwig
Mechanistic Studies of Ruthenium-Catalyzed Anti-Markovnikov Hydroamination of Vinylarenes: Intermediates and Evidence for Catalysis through p-Arene Complexes.
J. Am. Chem. Soc.2005,
127, 5756-5757.
152. Tsukada, N. and J. F. Hartwig
Intermolecular and Intramolecular, Platinum-Catalyzed, Acceptorless Dehydrogenative Coupling of Hydrosilanes with Aryl and Aliphatic Methyl C-H Bonds.
J. Am. Chem. Soc.2005,
127, 5022-5023.
150. Yan, X. Z., Pawlas, J., Goodson, T., III and J. F. Hartwig
Polaron Delocalization in Ladder Macromolecular Systems.
J. Am. Chem. Soc.2005,
127, 9105-9116.
149. Zhao, J., Goldman, A. S., and J. F. Hartwig
Oxidative Addition of Ammonia to Form a Stable Monomeric Amido Hydride Complex.
Science2005,
307, 1080-1082.
148. Zhao, J. and J. F. Hartwig
Acceptorless, Neat, Ruthenium-Catalyzed Dehydrogenative Cyclization of Diols to Lactones.
Organometallics2005,
24, 2441-2446.
147. Zhao, P., Krug, C., and J. F. Hartwig
Transfer of Amido Groups from Isolated Rhodium(I) Amides to Alkenes and Vinylarenes.
J. Am. Chem. Soc.2005,
127, 12066-12073.
145. Cook, K. S., Incarvito, C. D., Webster, C. E., Fan, Y., Hall, M. B. and J. F. Hartwig
Rhodium Silyl Boryl Hydride Complexes: Comparison of Bonding and the Rates of Elimination of Borane, Silane, and Dihydrogen.
Angew. Chem. Int. Ed.2004,
43, 5474-5477.
144. Culkin, D. A. and J. F. Hartwig
Carbon-Carbon Bond-Forming Reductive Elimination from Arylpalladium Complexes Containing Functionalized Alkyl Groups. Influence of Ligand Steric and Electronic Properties on Structure, Stability, and Reactivity.
Organometallics2004,
23, 3398-3416.
142. Krug, C. and J. F. Hartwig
Reactions of an Arylrhodium Complex with Aldehydes, Imines, Ketones, and Alkynones. New Classes of Insertion Reactions.
Organometallics2004,
23, 4594-4607.
141. Lawrence, J. D., Takahashi, M., Bae, C. and J. F. Hartwig
Regiospecific Functionalization of Methyl C-H Bonds of Alkyl Groups in Reagents with Heteroatom Functionality.
J. Am. Chem. Soc.2004,
126, 15334-15335.
140. Leitner, A., Larsen, J., Steffens, C. and J. F. Hartwig
Palladium-Catalyzed Addition of Mono- and Dicarbonyl Compounds to Conjugated Dienes.
J. Org. Chem.2004,
69, 7552-7557.
138. Liu, X. and J. F. Hartwig
Palladium-Catalyzed a-Arylation of Trimethylsilyl Enolates of Esters and Imides. High Functional Group Tolerance and Stereoselective Synthesis of a-Aryl Carboxylic Acid Derivatives.
J. Am. Chem. Soc.2004,
126, 5182-5191.
137. Roy, A. H. and J. F. Hartwig
Oxidative Addition of Aryl Sulfonates to Palladium(0) Complexes of Mono- and Bidentate Phosphines. Mild Addition of Aryl Tosylates and the Effects of Anions on Rate and Mechanism.
Organometallics2004,
23, 194-202.
136. Roy, A. H. and J. F. Hartwig
Reductive Elimination of Aryl Halides upon Addition of Hindered Alkylphosphines to Dimeric Arylpalladium(II) Halide Complexes.
Organometallics2004,
23, 1533-1541.
135. Shekhar, S. and J. F. Hartwig
Distinct Electronic Effects on Reductive Eliminations of Symmetrical and Unsymmetrical Bis-Aryl Platinum Complexes..
J. Am. Chem. Soc.2004,
126, 13016-13027.
134. Shu, C., Leitner, A. and J. F. Hartwig
Enantioselective Allylation of Aromatic Amines after In Situ Generation of an Activated Cyclometalated Iridium Catalyst.
Angew. Chem. Int. Ed.2004,
43, 4797-4800.
133. Shu, C. and J. F. Hartwig
Iridium-Catalyzed Intermolecular Allylic Etherification with Aliphatic Alkoxides: Asymmetric Synthesis of Dihydropyrans and Dihydrofurans.
Angew. Chem. Int. Ed.2004,
43, 4794-4797.
132. Stambuli, J. P., Incarvito, C. D., Buhl, M. and J. F. Hartwig
Synthesis, Structure, Theoretical Studies, and Ligand Exchange Reactions of Monomeric, T-Shaped Arylpalladium(II) Halide Complexes with an Additional, Weak Agostic Interaction.
J. Am. Chem. Soc.2004,
126, 1184-1194.
130. Yamashita, M. and J. F. Hartwig
Synthesis, Structure, and Reductive Elimination Chemistry of Three-Coordinate Arylpalladium Amido Complexes.
J. Am. Chem. Soc.2004,
126, 5344-5345.
128. Anastasi, N. R., Waltz, K. M., Weerakoon, W. L., and J. F. Hartwig
A short synthesis of tetraalkoxydiborane(4) reagents.
Organometallics2003,
22, 365-369.
127. Culkin, D. A. and J. F. Hartwig
Palladium-catalyzed alpha-arylation of carbonyl compounds and nitriles.
Acc. Chem. Res.2003,
36, 234-245.
126. Hama, T., Liu, X., Culkin, D. A., and J. F. Hartwig
Palladium-Catalyzed a-Arylation of Esters and Amides under More Neutral Conditions.
J. Am. Chem. Soc.2003,
125, 11176-11177.
125. Hooper, M. W., Utsunomiya, M., and J. F. Hartwig
Scope and mechanism of palladium-catalyzed amination of five-membered heterocyclic halides.
J. Org. Chem.2003,
68, 2861-2873.
124. Hooper, M. W. and J. F. Hartwig
Understanding the Coupling of Heteroaromatic Substrates: Synthesis, Structures, and Reductive Eliminations of Heteroarylpalladium Amido Complexes.
Organometallics2003,
22, 3394-3403.
123. Ishiyama, T., Takagi, J., Yonekawa, Y., Hartwig, J. F., and N. Miyaura
Iridium-Catalyzed Direct Borylation of Five-Membered Heteroarenes by Bis(pinacolato)diboron: Regioselective, Stoichiometric, and Room Temperature Reactions.
Advanced Synthesis and Catalysis2003,
345, 1103-1106.
122. Ishiyama, T., Nobuta, Y., Hartwig, J. F., and N. Miyaura
Room Temperature Borylation of Arenes and Heteroarenes Using Stoichiometric Amounts of Pinacolborane Catalyzed by Iridium Complexes in an Inert Solvent..
Chemical Communications2003,
23, 2924-2925.
121. Kanzelberger, M., Zhang, X., Emge, T. J., Goldman, A. S., Zhao, J., Incarvito, C. D., and J. F. Hartwig
Distinct Thermodynamics for the Formation and Cleavage of N-H Bonds in Aniline and Ammonia. Directly-Observed Reductive Elimination of Ammonia from an Isolated Amido Hydride Complex.
J. Am. Chem. Soc.2003,
125, 13644-13645.
120. Kiener, C. A., Shu, C., Incarvito, C. D., and J. F. Hartwig
Identification of an Activated Catalyst in the Iridium-Catalyzed Allylic Amination and Etherification. Increased Rates, Scope, and Selectivity.
J. Am. Chem. Soc.2003,
125, 14272 -14273.
119. Liu, X. and J. F. Hartwig
Palladium-catalyzed a-arylation of azlactones to form quaternary amino acid derivatives..
Org. Lett.2003,
5, 1915-1918.
118. Lopez, F., Ohmura, T., and J. F. Hartwig
Regio- and Enantioselective Iridium-Catalyzed Intermolecular Allylic Etherification of Achiral Allylic Carbonates with Phenoxides..
J. Am. Chem. Soc.2003,
125, 3426-3427.
117. Mann, G., Shelby, Q., Roy, A. H., and J. F. Hartwig
Electronic and Steric Effects on the Reductive Elimination of Diaryl Ethers from Palladium(II).
Organometallics2003,
22, 2775-2789.
116. Roy, A. H. and J. F. Hartwig
Directly Observed Reductive Elimination of Aryl Halides from Monomeric Arylpalladium(II) Halide Complexes.
J. Am. Chem. Soc.2003,
125, 13944-13945.
115. Roy, A. H. and J. F. Hartwig
Oxidative Addition of Aryl Tosylates to Palladium(0) and Coupling of Unactivated Aryl Tosylates at Room Temperature.
J. Am. Chem. Soc.2003,
125, 8704-8705.
113. Stauffer, S. R. and J. F. Hartwig
Fluorescence Resonance Energy Transfer (FRET) as a High-Throughput Assay for Coupling Reactions. Arylation of Amines as a Case Study..
J. Am. Chem. Soc.2003,
125, 6977-6985.
112. Utsunomiya, M., Kawatsura, M., and J. F. Hartwig
Palladium-Catalyzed Equilibrium Addition of Acidic OH Groups across Dienes.
Angew. Chem. Int. Ed.2003,
42, 5865-5868.
111. Utsunomiya, M., Kuwano, R., Kawatsura, M., and J. F. Hartwig
Rhodium-Catalyzed Anti-Markovnikov Hydroamination of Vinylarenes.
J. Am. Chem. Soc.2003,
125, 5608-5609.
109. Webster, C. E., Fan, Y., Hall, M. B., Kunz, D., and J. F. Hartwig
Experimental and Computational Evidence for a Boron-Assisted, Sigma-Bond Metathesis Pathway for Alkane Borylation.
J. Am. Chem. Soc.2003,
125, 858-859.
108. Yamashita, M., Cuevas Vicario, J. V., and J. F. Hartwig
Trans Influence on the Rate of Reductive Elimination. Reductive Elimination of Amines from Isomeric Arylpalladium Amides with Unsymmetrical Coordination Spheres.
J. Am. Chem. Soc.2003,
125, 16347-16360.
104. Alcazar-Roman, L. M. and J. F. Hartwig
Mechanistic studies on oxidative addition of aryl halides and triflates to Pd(BINAP)2 and structural characterization of the product from aryl triflate addition in the presence of amine.
Organometallics2002,
21, 491-502.
103. Beare, N. A. and J. F. Hartwig
Palladium-catalyzed arylation of malonates and cyanoesters using sterically hindered trialkyl- and ferrocenyldialkylphosphine ligands.
J. Org. Chem.2002,
67, 541-555.
102. Culkin, D. A. and J. F. Hartwig
Synthesis, characterization, and reactivity of arylpalladium cyanoalkyl complexes: Selection of catalysts for the alpha-arylation of nitriles.
J. Am. Chem. Soc.2002,
124, 9330-9331.
100. Ishiyama, T., Takagi, J., Hartwig, J. F., and N. Miyaura
A stoichiometric aromatic C-H borylation catalyzed by iridium(I)/2,2 '-bipyridine complexes at room temperature.
Angew. Chem. Int. Ed.2002,
41, 3056-3058.
99. Ishiyama, T., Takagi, J., Ishida, K., Miyaura, N., Anasrasi, N. R., and J. F. Hartwig
Mild iridium-catalyzed borylation of arenes. High turnover numbers, room temperature reactions, and isolation of a potential intermediate.
J. Am. Chem. Soc.2002,
124, 390-391.
98. Jorgensen, M., Lee, S., Liu, X., Wolkowski, J. P., and J. F. Hartwig
Efficient synthesis of a-aryl esters by room-temperature palladium-catalyzed coupling of aryl halides with ester enolates.
J. Am. Chem. Soc.2002,
124, 12557-12565.
97. Kataoka, N., Shelby, Q., Stambuli, J. P., and J. F. Hartwig
Air stable, sterically hindered ferrocenyl dialkylphosphines for palladium-catalyzed C-C, C-N, and C-O bond-forming cross-couplings.
J. Org. Chem.2002,
67, 5553-5566.
96. Kondo, Y., Garcia-Cuadrado, D., Hartwig, J. F., Boaen, N. K., Wagner, N. L. and A. M. Hillmyer
Rhodium-catalyzed, regiospecific functionalization of polyolefins in the melt.
J. Am. Chem. Soc.2002,
124, 1164-1165.
94. Kuwano, R., Utsunomiya, M., and J. F. Hartwig
Aqueous hydroxide as a base for palladium-catalyzed amination of aryl chlorides and bromides.
J. Org. Chem.2002,
67, 6479-6486.
93. Nettekoven, U. and J. F. Hartwig
A new pathway for hydroamination. Mechanism of palladium-catalyzed addition of anilines to vinylarenes.
J. Am. Chem. Soc.2002,
124, 1166-1167.
92. Ohmura, T. and J. F. Hartwig
Regio- and enantioselective allylic amination of achiral allylic esters catalyzed by an iridium-phosphoramidite complex.
J. Am. Chem. Soc.2002,
124, 15164-15165.
91. Pawlas, J., Nakao, Y., Kawatsura, M., J. F. Hartwig
A general nickel-catalyzed hydroamination of 1,3-dienes by alkylamines: Catalyst selection, scope, and mechanism.
J. Am. Chem. Soc.2002,
124, 3669-3679.
90. Ranasinghe, M. I., Varnavski, O. P., Pawlas, J., Hauck, S. I., Louie, J., Hartwig, J. F., and T. Goodson III
Femtosecond excitation energy transport in triarylamine dendrimers.
J. Am. Chem. Soc.2002,
124, 6520-6521.
89. Schlummer, B. and J. F. Hartwig
Bronsted acid-catalyzed intramolecular hydroamination of protected alkenylamines. Synthesis of pyrrolidines and piperidines.
Org. Lett.2002,
4, 1471-1474.
88. Stambuli, J. P., Kuwano, R., and J. F. Hartwig
Unparalleled rates for the activation of aryl chlorides and bromides: Coupling with amines and boronic acids in minutes at room temperature.
Angew. Chem. Int. Ed.2002,
41, 4746-4748.
87. Stambuli, J. P., Buhl, M., and J. F. Hartwig
Synthesis, characterization, and reactivity of monomeric, arylpalladium halide complexes with a hindered phosphine as the only dative ligand.
J. Am. Chem. Soc.2002,
124, 9346-9347.
86. Takagi, J., Sato, K., Hartwig, J. F., Ishiyama, T., and N. Miyaura
Iridium-catalyzed C-H coupling reaction of heteroaromatic compounds with bis(pinacolato)diboron: regioselective synthesis of heteroarylboronates.
Tetrahedron Letters2002,
43, 5649-5651.
85. Wolkowski, J. P. and J. F. Hartwig
Generation of Reactivity from Typically Stable Ligands: C-C Bond-Forming Reductive Elimination from Aryl Palladium(II) Complexes of Malonate Anions.
Angew. Chem. Int. Ed.2002,
114, 4465-4467.
83. Chae, H. K., Eddaoudi, M., Kim, J., Hauck, S. I., Hartwig, J. F., O'Keeffe, M., and O. M. Yaghi
Tertiary building units: Synthesis, structure, and porosity of a metal-organic dendrimer framework (MODF-1).
J. Am. Chem. Soc.2001,
123, 11482-11483.
82. Culkin, D. A. and J. F. Hartwig
C-C bond-forming reductive elimination of ketones, esters, and amides from isolated arylpalladium(II) enolates.
J. Am. Chem. Soc.2001,
123, 5816-5817.
79. Kawatsura, M. and J. F. Hartwig
Transition metal-catalyzed addition of amines to acrylic acid derivatives. A high-throughput method for evaluating hydroamination of primary and secondary alkylamines.
Organometallics2001,
20, 1960-1964.
78. Lee, S., Beare, N. A., and J. F. Hartwig
Palladium-catalyzed alpha-arylation of esters and protected amino acids.
J. Am. Chem. Soc.2001,
123, 8410-8411.
77. Lee, S., M. Jorgensen, and J. F. Hartwig
Palladium-catalyzed synthesis of arylamines from aryl halides and lithium bis(trimethylsilyl)amide as an ammonia equivalent.
Org. Lett.2001,
3, 2729-2732.
76. Lee, S. and J. F. Hartwig
Improved catalysts for the palladium-catalyzed synthesis of oxindoles by amide a-arylation. Rate acceleration, use of aryl chloride substrates, and a new carbene ligand for asymmetric transformations.
J. Org. Chem.2001,
66, 3402-3415.
75. Lober, O., Kawatsura, M., and J. F. Hartwig
Palladium-catalyzed hydroamination of 1,3-dienes: A colorimetric assay and enantioselective additions.
J. Am. Chem. Soc.2001,
123, 4366-4367.
73. Stambuli, J. P., Stauffer, S. R., Shaughnessy, K. H., and J. F. Hartwig
Screening of homogeneous catalysts by fluorescence resonance energy transfer. Identification of catalysts for room-temperature Heck reactions.
J. Am. Chem. Soc.2001,
123, 2677-2678.
72. Stauffer, S. R., Beare, N .A., Stambuli, J. P., and J. F. Hartwig
Palladium-catalyzed arylation of ethyl cyanoacetate. Fluorescence resonance energy transfer as a tool for reaction discovery.
J. Am. Chem. Soc.2001,
123, 4641-4642.
71. Zhao, J., Hesslink, H., and J. F. Hartwig
Mechanism of b-hydrogen elimination from square planar iridium(I) alkoxide complexes with labile dative ligands.
J. Am. Chem. Soc.2001,
123, 7220-7227.
70. Shelby, Q.; Kataoka, N.; Mann, G.; Hartwig, J.F.
Unusual in situ Ligand Modification to Generate a Catalyst for Room Temperature Aromatic C-O Bond Formation.
J. Am. Chem. Soc.2000,
122, 10718-10719.
69. Alcazar-Roman, L. M., Hartwig, J. F., Rheingold, A. L., Liable-Sands, L. M., and I. A. Guzei
Mechanistic studies of the palladium-catalyzed amination of aryl halides and the oxidative addition of aryl bromides to Pd(BINAP)2 and Pd(DPPF)2: An unusual case of zero-order kinetic behavior and product inhibition.
J. Am. Chem. Soc.2000,
122, 4618-4630.
68. Chen, H. Y., Schlecht, S., Semple, T. C., and J. F. Hartwig
Thermal, catalytic, regiospecific functionalization of alkanes.
Science2000,
287, 1995-1997.
67. Hartwig, J. F. and C. N. Muhoro
Mechanistic studies of titanocene-catalyzed alkene and alkyne hydroboration: Borane complexes as catalytic intermediates.
Organometallics2000,
19, 30-38.
66. Ishiyama, T. and J. Hartwig
A Heck-type reaction involving carbon-heteroatom double bonds. Rhodium(I)-catalyzed coupling of aryl halides with N-pyrazyl aldimines.
J. Am. Chem. Soc.2000,
122, 12043-12044.
65. Kawatsura, M. and J. F. Hartwig
Palladium-catalyzed intermolecular hydroamination of vinylarenes using arylamines.
J. Am. Chem. Soc.2000,
122, 9546-9547.
63. Stauffer, S. R., Lee, S., Stambuli, J. P., Hauck, S. I., and J. F. Hartwig
High turnover number and rapid, room-temperature amination of chloroarenes using saturated carbene ligands.
Org. Lett.2000,
2, 1423-1426.
61. Chen, H. Y. and J. F. Hartwig
Catalytic, regiospecific end-functionalization of alkanes: Rhenium-catalyzed borylation under photochemical conditions.
Angew. Chem. Int. Ed.1999,
38, 3391-3393.
60. Goodson, F. E., Hauck, S. I., and J. F. Hartwig
Palladium-catalyzed synthesis of pure, regiodefined polymeric triarylamines.
J. Am. Chem. Soc.1999,
121, 7527-7539.
58. Hartwig, J. F., Kawatsura, M., Hauck, S. I., Shaughnessy, K. H., and L. M. Alcazar-Roman
Room-temperature palladium-catalyzed amination of aryl bromides and chlorides and extended scope of aromatic C-N bond formation with a commercial ligand.
J. Org. Chem.1999,
64, 5575-5580.
57. Hauck, S. I., Lakshmi, K. V. and J. F. Hartwig
Tetraazacyclophanes by palladium-catalyzed aromatic amination. Geometrically defined, stable, high-spin diradicals.
Org. Lett.1999,
1, 2057-2060.
56. Kawatsura, M. and J. F. Hartwig
Simple, highly active palladium catalysts for ketone and malonate arylation: Dissecting the importance of chelation and steric hindrance.
J. Am. Chem. Soc.1999,
121, 1473-1478.
55. Mann, G., Incarvito, C. D., Rheingold, A. L., and J. F. Hartwig
Palladium-catalyzed C-O coupling involving unactivated aryl halides. Sterically induced reductive elimination to form the C-O bond in diaryl ethers.
J. Am. Chem. Soc.1999,
121, 3224-3225.
53. Shaughnessy, K. H., Kim, P., and J. F. Hartwig
A fluorescence-based assay for high-throughput screening of coupling reactions. Application to Heck chemistry.
J. Am. Chem. Soc.1999,
121, 2123-2132.
52. Waltz, K. M., Muhoro, C. N., and J. F. Hartwig
C-H activation and functionalization of unsaturated hydrocarbons by transition-metal boryl complexes.
Organometallics1999,
18, 3383-3393.
51. Driver, M. S. and J. F. Hartwig
Oxidative addition and reductive elimination reactions of trans-[Ir(PPh3)2(CO)(NC4H4)] and trans,cis-[Ir(PPh3)2(H)2(CO)(NC4H4)] including N-H bond-forming reductive elimination of pyrrole.
Organometallics1998,
17, 1134-1143.
50. Goodson, F. E. and J. F. Hartwig
Regiodefined poly(N-arylaniline)s and donor-acceptor copolymers via palladium-mediated amination chemistry.
Macromolecules1998,
31, 1700-1703.
49. Hamann, B. C. and J. F. Hartwig
Sterically hindered chelating alkyl phosphines provide large rate accelerations in palladium-catalyzed amination of aryl iodides, bromides, and chlorides, and the first amination of aryl tosylates.
J. Am. Chem. Soc.1998,
120, 12706-12706.
48. Hamann, B. C. and J. F. Hartwig
Sterically hindered chelating alkyl phosphines provide large rate accelerations in palladium-catalyzed amination of aryl iodides, bromides, and chlorides, and the first amination of aryl tosylates.
J. Am. Chem. Soc.1998,
120, 7369-7370.
47. Hamann, B. C. and J. F. Hartwig
Systematic variation of bidentate ligands used in aryl halide amination. Unexpected effects of steric, electronic, and geometric perturbations.
J. Am. Chem. Soc.1998,
120, 3694-3703.
46. Hartwig, J. F.
Carbon-heteroatom bond-forming reductive eliminations of amines, ethers, and sulfides.
Acc. Chem. Res.1998,
31, 852-860.
45. Hartwig, J. F.
Transition metal catalyzed synthesis of arylamines and aryl ethers from aryl halides and triflates: Scope and mechanism.
Angew. Chem. Int. Ed.1998,
37, 2047-2067.
44. Hartwig, J. F.
Synthesis, structure, and reactivity of a palladium hydrazonato complex: A new type of reductive elimination reaction to form C-N bonds and catalytic arylation of benzophenone hydrazone.
Angew. Chem. Int. Ed.1998,
37, 2090-2093.
43. Louie, J. and J. F. Hartwig
The largest discrete oligo(m-aniline). An exponential growth strategy using palladium-catalyzed amination of aryl sulfonates.
Macromolecules1998,
31, 6737-6739.
42. Mann, G., Baranano, D., Hartwig, J. F., Rheingold, A. L., and I. A. Guzei
Carbon-sulfur bond-forming reductive elimination involving sp-, sp2-, and sp3-hybridized carbon. Mechanism, steric effects, and electronic effects on sulfide formation.
J. Am. Chem. Soc.1998,
120, 9205-9219.
41. Mann, G., Hartwig, J. F., Driver, M. S., and C. Fernandez-Rivas
Palladium-catalyzed C-N(sp2) bond formation: N-arylation of aromatic and unsaturated nitrogen and the reductive elimination chemistry of palladium azolyl and methyleneamido complexes.
J. Am. Chem. Soc.1998,
120, 827-828.
40. Shaughnessy, K. H., Hamann, B. C., and J. F. Hartwig
Palladium-catalyzed inter- and intramolecular alpha-arylation of amides. Application of intramolecular amide arylation to the synthesis of oxindoles.
J. Org. Chem.1998,
63, 6546-6553.
38. Baranano, D.; Mann, G., and Hartwig, J. F.
Nickel and palladium-catalyzed cross-couplings that form carbon-heteroatom and carbon-element bonds.
Current Organic Chemistry1997,
1, 287-305.
37. Driver, M. S. and J. F. Hartwig
Energetics and mechanism of alkylamine N-H bond cleavage by palladium hydroxides: N-H activation by unusual acid-base chemistry.
Organometallics1997,
16, 5706-5715.
36. Driver, M. S. and J. F. Hartwig
Carbon-nitrogen-bond-forming reductive elimination of arylamines from palladium(II) phosphine complexes.
J. Am. Chem. Soc.1997,
119, 8232-8245.
35. Hamann, B. C. and J. F. Hartwig
Palladium-catalyzed direct alpha-arylation of ketones. Rate acceleration by sterically hindered chelating ligands and reductive elimination from a transition metal enolate complex.
J. Am. Chem. Soc.1997,
119, 12382-12383.
34. Hartwig, J. F.
Palladium-Catalyzed Amination of Aryl Halides: Mechanism and Rational Catalyst Design.
Synlett1997,
1997, 329-340.
33. Louie, J., Hartwig, J. F., and A. J. Fry
Discrete high molecular weight triarylamine dendrimers prepared by palladium-catalyzed amination.
J. Am. Chem. Soc.1997,
119, 11695-11696.
32. Louie, J., Driver, M. S., Hamann, B. C., and J. F. Hartwig
Palladium-catalyzed amination of aryl triflates and importance of triflate addition rate.
J. Org. Chem.1997,
62, 1268-1273.
31. Mann, G. and J. F. Hartwig
Palladium-catalyzed formation of diaryl ethers from aryl bromides. Electron poor phosphines enhance reaction yields.
Tetrahedron Letters1997,
38, 8005-8008.
30. Mann, G. and J. F. Hartwig
Nickel- vs palladium-catalyzed synthesis of protected phenols from aryl halides.
J. Org. Chem.1997,
62, 5413-5418.
28. Waltz, K. M. and J. F. Hartwig
Selective functionalization of alkanes by transition-metal boryl complexes.
Science1997,
277, 211-213.
27. Driver, M. S. and J. F. Hartwig
A second-generation catalyst for aryl halide amination: Mixed secondary amines from aryl halides and primary amines catalyzed by (DPPF)PdCl2.
J. Am. Chem. Soc.1996,
118, 7217-7218.
26. Driver, M. S. and J. F. Hartwig
General N-H activation of primary alkylamines by a late transition-metal complex.
J. Am. Chem. Soc.1996,
118, 4206-4207.
24. Hartwig, J. F., Muhoro, C. N., He, X., Eisenstein, O., Bosque, R., and F. Maseras
Catecholborane bound to titanocene. Unusual coordination of ligand sigma-bonds.
J. Am. Chem. Soc.1996,
118, 10936-10937.
23. Hartwig, J. F.
Directly-observed b-hydrogen elimination of a late transition metal amido complex and unusual fate of imine byproducts.
J. Am. Chem. Soc.1996,
118, 7010-7011.
22. Hartwig, J. F., Richards, S., Baranano, D., and F. Paul
Influences on the relative rates for C-N bond-forming reductive elimination and beta-hydrogen elimination of amides. A case study on the origins of competing reduction in the palladium-catalyzed amination of aryl halides.
J. Am. Chem. Soc.1996,
118, 3626-3633.
19. He, X. M. and J. F. Hartwig
Boryls bound to iron carbonyl. Structure of a rare bis(boryl) complex, synthesis of the first anionic boryl, and reaction chemistry that includes the synthetic equivalent of boryl anion transfer.
Organometallics1996,
15, 400-407.
17. Louie, J., F. Paul, and J. F. Hartwig
Catalysis with platinum-group alkylamido complexes, the active palladium amide in catalytic aryl halide aminations as deduced from kinetic data and independent generation.
Organometallics1996,
15, 2794-2805.
16. Mann, G. and J. F. Hartwig
Palladium alkoxides: Potential intermediacy in catalytic amination, reductive elimination of ethers, and catalytic etheration. Comments on alcohol elimination from Ir(III).
J. Am. Chem. Soc.1996,
118, 13109-13110.
15. Rablen, P. R. and J. F. Hartwig
Accurate borane sequential bond dissociation energies by high-level ab initio computational methods.
J. Am. Chem. Soc.1996,
118, 4648-4653.
14. Baranano, D. and J. F. Hartwig
Carbon-Heteroatom Bond-Forming Reductive Elimination - Mechanism, Importance of Trapping Reagents, and Unusual Electronic Effects During Formation of Aryl Sulfides.
J. Am. Chem. Soc.1995,
117, 2937-2938.
13. Driver, M. S. and J. F. Hartwig
A Rare, Low-Valent Alkylamido Complex, a Diphenylamido Complex, and Their Reductive Elimination of Amines by 3-Coordinate Intermediates.
J. Am. Chem. Soc.1995,
117, 4708-4709.
12. Paul, F., Patt, J., and J. F. Hartwig
Structural Characterization and Simple Synthesis of (Pd[P(O-Tol)3]2), Dimeric Palladium(II) Complexes Obtained by Oxidative Addition of Aryl Bromides, and Corresponding Monometallic Amine Complexes.
Organometallics1995,
14, 3030-3039.
11. Hartwig, J. F. and F. Paul
Oxidative Addition of Aryl Bromide after Dissociation of Phosphine from a 2-Coordinate Palladium(0) Complex, Bis(Tri-O-Tolylphosphine)Palladium(0).
J. Am. Chem. Soc.1995,
117, 5373-5374.
10. Louie, J. and J. F. Hartwig
Transmetalation Involving Organotin Aryl, Thiolate, and Amide Compounds - an Unusual Type of Dissociative Ligand Substitution-Reaction.
J. Am. Chem. Soc.1995,
117, 11598-11599.
9. Louie, J. and J. F. Hartwig
Palladium-Catalyzed Synthesis of Arylamines from Aryl Halides - Mechanistic Studies Lead to Coupling in the Absence of Tin Reagents.
Tetrahedron Letters1995,
36, 3609-3612.
7. Hartwig, J. F. and S. R. De Gala
A Continuum Resulting from Equilibrium between 2 Structural Extremes in Tungstenocene and Niobocene Boryl and Hydridoborate Complexes - p-Bonding in a d2 Boryl System and the First d0 Boryl Complex.
J. Am. Chem. Soc.1994,
116, 3661-3662.
6. Hartwig, J. F., Bhandari, S., and P. R. Rablen
Addition of Catecholborane to a Ruthenium-Alkyl - Evidence for Sigma-Bond Metathesis with a Low-Valent, Late Transition-Metal.
J. Am. Chem. Soc.1994,
116, 1839-1844.
5. Paul, F., Patt, J., and J. F. Hartwig
Palladium-Catalyzed Formation of Carbon-Nitrogen Bonds - Reaction Intermediates and Catalyst Improvements in the Hetero Cross-Coupling of Aryl Halides and Tin Amides.
J. Am. Chem. Soc.1994,
116, 5969-5970.
4. Rablen, P. R., Hartwig, J. F., and S. P. Nolan
First Transition Metal-Boryl Bond-Energy and Quantitation of Large Differences in Sequential Bond-Dissociation Energies of Boranes.
J. Am. Chem. Soc.1994,
116, 4121-4122.
3. Hartwig, J. F. and S. Huber
Transition-Metal Boryl Complexes - Structure and Reactivity of CpFe(CO)2Bcat and CpFe(CO)2BPh2.
J. Am. Chem. Soc.1993,
115, 4908-4909.
2. Burn, M.J.; Fickes, M.G.; Hartwig, J.F.; Hollander, F.J.; Bergman, R.G.
Synthesis of Monomeric Ruthenium Hydroxo Complexes (PMe3)4Ru(R)(OH) (R=H, Me) and a Unique Dimeric Ruthenium Hydroxo Water Complex [trans-Ru(H)(OH)(DMPE)2.H2O]2.
J. Am. Chem. Soc.1993,
115, 5875-5876.
1. Hartwig, J.F.; Pil, P.M.; Lippard, S.J.
Synthesis and DNA Binding Properties of a Cisplatin Analogue Containing a Tethered Dansyl Group.
J. Am. Chem. Soc.1992,
114, 8292-8293.
