OUR CHEMISTRY

Our research group aims to discover, develop and understand new transition metal-catalyzed reactions. The discovery of fundamentally new transition metal chemistry and its development into practical, catalytic synthetic methods is a theme of our research.

RECENT NEWS



March 2019: Dr. Xingyu Jiang will begin his new position as a Senior Scientist at Pharmacyclics, an AbbVie company.

December 2018: Dr. Mingshuo Zeng will begin her new position as a Senior Scientist in the Department of Discovery Chemistry at Genentech, South San Francisco, CA.

June 2018: Dr. Taegyo Lee will begin his new position as a Senior Scientist at Pfizer Inc., Groton, CT.

April 2018: Dr. Eunhye Kang will begin her new position as a Scientist at LG in South Korea.

April 2018: Dr. Haoquan Li will begin his new position as a Senior Scientist at Dow Chemical Company, Midland, MI.

April 2018: Dr. Ala Bunescu will begin her new position as a Postdoctoral Fellow at Dept. of Chemistry, University of Cambridge, United Kingdom.

April 2018: Dr. Masahiro Kojima will begin his new position as an Assistant Professor at Dept. of Chemistry, Hokkaido University, Sapporo, Japan.

April 2018: Dr. Qing-Wei Zhang will begin his new position as an Assistant Professor at Dept. of Chemistry, University of Science and Technology of China.

January 2018: Dr. Sarah Lee will begin her new position as an Assistant Professor at Dept. of Chemistry, Yonsei University, Seoul, South Korea.

January 2018: Dr. Rhett Baillie will begin his new position as a Scientist at Dow Chemical Company, Houston, TX.

RECENT PUBLICATIONS

He, Z., Li, H., Haydl, A. M., Whiteker, G. T., Hartwig, J. F. Trimethylphosphate as a Methylating Agent for Cross Coupling: A Slow-Release Mechanism for the Methylation of Arylboronic Esters. J. Am. Chem. Soc.  2018140,  17197-17202.
Su, B.; Lee, T.; Hartwig, J.F. Iridium-Catalyzed, β-Selective C(sp3)-H Silylation of Aliphatic Amines to Form Silapyrrolidines and 1,2-Amino Alcohols. J. Am. Chem. Soc.  2018140,  18032-18038.
Peacock, D.M.; Jiang, Q.; Cundari, T.R.; Hartwig, J.F. Reductive Elimination to Form C(sp3)-N Bonds from Palladium(II) Primary Alkyl Complexes. Organometallics  201837,  3243-3247.
Butcher, T.W.; Hartwig, J.F. Enantioselective Synthesis of Tertiary Allylic Fluorides by Iridium-Catalyzed Allylic Fluoroalkylation. Angew. Chem. Int. Ed.  201857,  13125-13129.
Zhang, Q.; Hartwig, J.F. Synthesis of Heteroaromatic Trifluoromethyl Ethers with Trifluoromethyl Triflate as the Source of the Trifluoromethoxy Group. Chem. Comm.  201854,  10124-10127.
Litman, Z.C.; Wang, Y.; Zhao, H.; Hartwig, J.F. Cooperative asymmetric reactions combining photocatalysis and enzymatic catalysis. Nature  2018560,  355-359.
Su, B.; Hartwig, J.F. Iridium‐Catalyzed, Silyl‐Directed, peri‐Borylation of C-H Bonds in Fused Polycyclic Arenes and Heteroarenes. Angew. Chem. Int. Ed.  201857,  10163-10167.
Wang, J.Y.; Strom, A.E.; Hartwig, J.F. Mechanistic Studies of Palladium-Catalyzed Aminocarbonylation of Aryl Chlorides with Carbon Monoxide and Ammonia. J. Am. Chem. Soc.  2018140,  7979-7993.
Peacock, D.M.; Jiang, Q.; Hanley, P.S.; Cundari, T.R.; Hartwig, J.F. Reductive Elimination from Phosphine-​ligated Alkylpalladium(II) Amido Complexes to Form sp3 Carbon-​Nitrogen Bonds. J. Am. Chem. Soc.  2018140,  4893-4904.
Jiang, X.; Boehm, P.; Hartwig, J.F. Stereodivergent Allylation of Azaaryl Acetamides and Acetates by Synergistic Iridium and Copper Catalysis. J. Am. Chem. Soc.  2018140,  1239-1242.